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4D ultrasound evaluation of fetal neurobehavioral development

Research Project

Project/Area Number 25462561
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKagawa University

Principal Investigator

Hata Toshiyuki  香川大学, 医学部, 教授 (20156334)

Co-Investigator(Kenkyū-buntansha) KANENISHI Kenji  香川大学, 医学部附属病院, 准教授 (10263906)
TANAKA Hirokazu  香川大学, 医学部, 准教授 (80207125)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords4次元超音波 / 胎児行動学 / 胎児表情 / 胎児中枢神経系の発達評価法 / KANETテスト / Fetal consciousness / 4次元超音波 / 胎児の表情 / FOMS評価法 / 4D ultrasound / Fetal facial expression / Fetal behavior / Fetal emotion / Fetal awarenss / Inter-twin contact / KANET score
Outline of Final Research Achievements

We found that a fetus may prepare for feeding after birth in the second half of pregnancy. Moreover, frequencies of complicated facial expressions such as smiling and scowling may increase with advancing gestation due to the development of the fetal brain and central nervous system. First study using KANET suggests that ethnicity should be considered when evaluating fetal behavior, especially during assessment of fetal facial expressions. Scond study suggests that the level of relaxation of pregnant women may affect fetal behavior, particularly the rate of eye blinking. Third study suggests that 4D ultrasound study examining fetal behavior does not need to consider the factor of fetal sex.
During this study period, we disclosed the characteristics of fetal facial expressions in the second half of pregnancy. Moreover, we are the first to document the usefulness of KANET test for evaluating fetal brain and central nervous system in Japan.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (41 results)

All 2016 2015 2014 2013

All Journal Article (34 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 34 results,  Acknowledgement Compliant: 18 results) Presentation (4 results) (of which Invited: 4 results) Book (3 results)

  • [Journal Article] Does ethnicity have an effect on fetal behavior? A comparison of Asian and Caucasian poplations.2016

    • Author(s)
      Hanaoka U, Hata T, Kanenishi K, AboEllail MAM, Uematsu R, Konishi Y, Kusaka T, Noguchi J, Marumo G, Vasilj O, Kurjak A.
    • Journal Title

      J perinat Med

      Volume: 印刷中 Issue: 2 Pages: 217-221

    • DOI

      10.1515/jpm-2015-0036

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] HDlive silhouette mode in antenatal diagnosis of jejunal atresia.2016

    • Author(s)
      AboEllail MAM, Tanaka H, Mori N, Hanaoka U, Hata T.
    • Journal Title

      Ultrasound Obstet Gynecol

      Volume: 48 Issue: 1 Pages: 131-132

    • DOI

      10.1002/uog.15737

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] HDlive silhouette mode with spatiotemporal correlation in assessment of the fetal heart.2016

    • Author(s)
      Hata T, AboEllail MAM, Sajapala S, Ishimura M, Masaoka H.
    • Journal Title

      J Ultrasound Med

      Volume: 35 Issue: 7 Pages: 1489-1495

    • DOI

      10.7863/ultra.15.08061

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] HDlive Flow with HDlive silhouette mode in diagnosis of uterine artery pseudoaneurysm duraing pregnancy.2016

    • Author(s)
      Yamamoto K, AboEllail MAM, Ito M, Mori N, Kanenishi K, Tanaka H, Hata T.
    • Journal Title

      Ultrasound Obstet Gynecol

      Volume: 48 Issue: 1 Pages: 125-128

    • DOI

      10.1002/uog.15802

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dose parity have an effect on fetal behavior? A comparison between primi- and multiparas.2016

    • Author(s)
      Hata T, Hanaoka U, AboEllail MAM, Uematsu R, Noguchi J, Kusaka T, Kurjak A.
    • Journal Title

      Donald School J Ultrasound Obstet Gynecol

      Volume: 10 Pages: 99-102

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Four-dimansional power Doppler sonograophy with the HDlive silhouette mode in antenatal diagnosis of a right aortic arch wtih an aberrant left subcllavian artery.2016

    • Author(s)
      AboEllail MAM, Kanenishi K, Tenkumo C, Mori N, Kaytayama T, Koyano K Kusaka T, Hata T.
    • Journal Title

      J Ultrasound Med

      Volume: 35 Issue: 3 Pages: 661-663

    • DOI

      10.7863/ultra.15.05047

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] HDliveFlow and HDlive silhouette mode for diagnosis of molar pregnancy.2016

    • Author(s)
      AboEllail MAM, Ishimura M, Sajapala S, Yamamoto K, Tanaka T, Nitta E, Kanenishi K, Hata T.
    • Journal Title

      J Ultrasound Med

      Volume: 印刷中 Issue: 9 Pages: 2049-2052

    • DOI

      10.7863/ultra.15.11070

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Is there a sex difference in fetal behavior? A comparison of KANET test between male and female fetuses.2016

    • Author(s)
      Hata T, Hanaoka U, AboEllail MAM, Uematsu R, Noguchi J, Kusaka T, Kurjak A.
    • Journal Title

      J Perinat Med

      Volume: 印刷中 Issue: 5

    • DOI

      10.1515/jpm-2015-0387

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Fetal facial abnormalities: From conventional 2D Ultrasound to HDlive and HDlive silhouette mode.2016

    • Author(s)
      Sajapal S, AboEllail MAM, Kanenishi K, HataT.
    • Journal Title

      Donald School J Ultrasound Obstet Gynecol

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] HDlive image of meconium peritonitis.2015

    • Author(s)
      AboEllail MAM, Tanaka H, Mori N, Tanaka A, Kubo H, Shimono R, Hata T.
    • Journal Title

      Ultrasound Obstet Gynecol

      Volume: 45 Issue: 4 Pages: 494-496

    • DOI

      10.1002/uog.14778

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] HDlive image of circumvallate placenta.2015

    • Author(s)
      AboEllail MAM, Kanenishi K, Mori N, Kurobe A, Hata T.
    • Journal Title

      Ultrasound Obstet Gynecol

      Volume: 46 Issue: 4 Pages: 513-514

    • DOI

      10.1002/uog.14839

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] HDlive image of giant fetal hemangioma.2015

    • Author(s)
      AboEllail MAM, Hanaoka U, Numoto A, Hata T.
    • Journal Title

      J Ultrasound Med

      Volume: 34 Issue: 12 Pages: 2315-2318

    • DOI

      10.7863/ultra.15.01070

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Diagnosis of trncus arteriosus in the first trimester of pregnancy using four-dimensional color Doppler ultrasound.2015

    • Author(s)
      AboEllail MAM, Kanenishi K, Mori N, Kurobe A, Hata T.
    • Journal Title

      Ultrasound Obstet Gynecol

      Volume: 45 Issue: 6 Pages: 759-760

    • DOI

      10.1002/uog.14868

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] New 3D power Doppler (HDliveFlow) with HDlive silhouette mode for diagnosis of malignant ovarian tumor.2015

    • Author(s)
      Sajapala S, AboEllail MAM, Tanaka H, Nitta E, Kanenishi K, Hata T.
    • Journal Title

      Ultrasound Obstet Gynecol

      Volume: 印刷中 Issue: 6 Pages: 806-808

    • DOI

      10.1002/uog.15730

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] HdliveFlow in tha assessment of fetal circulation.2015

    • Author(s)
      Hata T, AboEllail MAM, Sajapala S, Ito M.
    • Journal Title

      Donald School Ultrasound Obstet Gynecol

      Volume: 9 Issue: 4 Pages: 462-470

    • DOI

      10.5005/jp-journals-10009-1433

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Fetal Hdlive silhouette mode in clinical practice.2015

    • Author(s)
      AboEllail MAM, Kanenishi K, Marum G, Masaoka H, Ejiri A, Hata T.
    • Journal Title

      Donald School Ultrasound Obstet Gynecol

      Volume: 9 Issue: 4 Pages: 413-419

    • DOI

      10.5005/jp-journals-10009-1428

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Fetal consioisness: 4D ultrasound study.2015

    • Author(s)
      Hata T, Kanenishi K, AboEllail MAM, marumo G, Kurjik A.
    • Journal Title

      Donald School Ultrasound Obstet Gynecol

      Volume: 9 Issue: 4 Pages: 471-474

    • DOI

      10.5005/jp-journals-10009-1434

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The potentil use of the fetal observable movement system in clincalpractice.2015

    • Author(s)
      Reissland N, Austen JM, Hanaoka U, AboEllail MAM, Uematsu R, Hata T.
    • Journal Title

      Donald School Ultrasound Obstet Gynecol

      Volume: 9 Issue: 4 Pages: 426-433

    • DOI

      10.5005/jp-journals-10009-1430

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] HDlive rendering images of cyclopia and a proboscis in a fetus with normal chromosomes at 32 weeks of gestation.2014

    • Author(s)
      Hata T, Hanaoka U, Mashima M.
    • Journal Title

      J Med Ultrasonics

      Volume: 41 Issue: 1 Pages: 109-110

    • DOI

      10.1007/s10396-013-0466-z

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] HDlive study of fetal development and behavior.2014

    • Author(s)
      Hata T, kanenishi K, Hanaoka U, Uematsu R, Marumo G, Tanaka H.
    • Journal Title

      Donald School J Ultrasound Obstet Gynecol

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] HDlive imaging of the fetal face in fetuses with autosomal trisomics.2014

    • Author(s)
      Hanaoka U, Tanaka H, Koyano K, Uematsu R, Kanenishi K, Hata T
    • Journal Title

      J Med Ultrasonics

      Volume: online publication Issue: 3 Pages: 339-342

    • DOI

      10.1007/s10396-014-0523-2

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 4D ultrasound study of fetal facial expressions at 20-24 weeks of gestation.2014

    • Author(s)
      Sato M, Kanenishi K, Hanaoka U, Noguchi J, Marumo G, Hata T.
    • Journal Title

      Int J Gynecol Obstet

      Volume: preliminary accepted

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Real-time tissue elastography of uterine sarcoma2014

    • Author(s)
      Nitta E, Kanenishi K, Itabashi N, tanaka H, Hata T.
    • Journal Title

      Arch Gynecol Obstet

      Volume: 289 Issue: 2 Pages: 463-465

    • DOI

      10.1007/s00404-013-2974-x

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] HDlive rendering image of adnexal tumors: preliminary report2014

    • Author(s)
      Hata T, Kanenishi K, Mashima M, Nitta E, Mori N, Hanaoka U, Tanaka H.
    • Journal Title

      J Med Ultrasonics

      Volume: 41 Issue: 2 Pages: 181-186

    • DOI

      10.1007/s10396-013-0489-5

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] HDlive of the fetal heart2014

    • Author(s)
      Hata T, Kanenishi K, Hanaoka U, Tanaka H.
    • Journal Title

      Donald School J Ultrasound Obstet Gynecol

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] HDlive imaging of early-stage nonhydropic mole2014

    • Author(s)
      Cajusay-Velasco S, Kanenishi K, Mashima M, Nishizawa C, Kawada K, Hata T.
    • Journal Title

      J Med Ultrasonics

      Volume: online Issue: 4 Pages: 507-509

    • DOI

      10.1007/s10396-014-0539-7

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 4D assessment of fetal facial expression during the latter stages of the second trimester.2013

    • Author(s)
      Kanenishi K, Hanaoka U, Noguchi J, Marumo G, Hata T.
    • Journal Title

      Int J Gynecol Obstet

      Volume: 121 Issue: 3 Pages: 257-260

    • DOI

      10.1016/j.ijgo.2013.01.018

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Four-dimensional HDlive rendering image of fetal facial expression: A pictorial assay.2013

    • Author(s)
      Hata T, Hanaoka U, Mashima M, Ishimura M, Marumo G, Kanenishi K.
    • Journal Title

      J Med Ultrasonics

      Volume: 40 Issue: 4 Pages: 437-441

    • DOI

      10.1007/s10396-013-0441-8

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] HDlive rendering images at 6 weeks of gestation.2013

    • Author(s)
      Hata T.
    • Journal Title

      J Med Ultrasonics

      Volume: 40 Issue: 4 Pages: 495-496

    • DOI

      10.1007/s10396-013-0450-7

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Antenatal three-dimensional sonographic diagnosis of presistent cloaca.2013

    • Author(s)
      Ishibashi M, tanaka H, Ito M, Uketa E, Mori N, Hanaoka U, Kanenishi K, Hata T.
    • Journal Title

      J Med Ultrasonics

      Volume: 40 Issue: 3 Pages: 275-277

    • DOI

      10.1007/s10396-012-0423-2

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Antenatal three-dimensional sonographic features of fetal biliary atresia.2013

    • Author(s)
      Mashima M, Tanaka H, Numoto A, Kubo H, Shimono R, Kusaka T, Itoh S, Hata T.
    • Journal Title

      J Med Ultrasonics

      Volume: 40 Issue: 3 Pages: 279-281

    • DOI

      10.1007/s10396-012-0425-0

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Three-dimensional HDlive rendering images of the fetal heart.2013

    • Author(s)
      Hata T, Mashima M, Ito M, Uketa E, Mori N, Ishimura M.
    • Journal Title

      Ultrasound Med Biol

      Volume: 39 Pages: 1513-1517

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Three- and four-dimensional sonographic diagnosis of fetal intra-abdominal umbilical vein varix.2013

    • Author(s)
      Austria BS, Hanaoka U, Sato M, Hata T.
    • Journal Title

      J Med Ultrasonics

      Volume: 41 Issue: 2 Pages: 245-246

    • DOI

      10.1007/s10396-013-0481-0

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] HDlive imaging of intra-amniotic umbilical vein with thrombosis2013

    • Author(s)
      Kanenishi K, Nitta E, Mashima M, Hanaoka U< Koyano K, Tanaka H, Hata T.
    • Journal Title

      Placenta

      Volume: 34 Pages: 1110-1112

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 胎児のこころ:4D超音波研究2016

    • Author(s)
      秦 利之
    • Organizer
      徳島大学産科婦人科研修セミナー 胎児超音波研修
    • Place of Presentation
      徳島
    • Year and Date
      2016-03-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 胎児にこころはあるのか?2016

    • Author(s)
      秦 利之
    • Organizer
      第7回滋賀医大精神医療講演会
    • Place of Presentation
      大津
    • Year and Date
      2016-03-06
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 胎児のこころについて考える2015

    • Author(s)
      秦 利之
    • Organizer
      第34回日本思春期学会
    • Place of Presentation
      大津
    • Year and Date
      2015-08-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 胎児のこころ―4D超音波の観察からわかること―2015

    • Author(s)
      秦 利之
    • Organizer
      日本赤ちゃん学会第15回学術集会
    • Place of Presentation
      高松
    • Year and Date
      2015-06-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Book] Fetal Development. Research on Brain Behavior, Environmental Influences, and Emerging Technologies2016

    • Author(s)
      Hata T, Kanenishi K, Hanaoka U, Uematsu R, Marumo G, Robert L, April ER, Scott RR, Takeshita H, Eduard JHM, Jan GN, Hernani G, Barbara SK, Nadja R, Aida SK, Leo RL, Vivette G, Curt AS, Bea R.H, Bruce CK, 他
    • Total Pages
      492
    • Publisher
      Splinger International Publishing AG, New York
    • Related Report
      2015 Annual Research Report
  • [Book] Advanced Topics on Three-dimensional Ultrasound in Obstetrics and Gynecology.2016

    • Author(s)
      Hata T, Kanenishi K, Tanaka H, Eberhard M, Edward AJ, Baba K, Daniela AB, Edward OM, Giuseppe R, Gabriela T, Michal Z, Rodrigo R, Liliam CR, Panagiotis A, Larry H, Heron WJ, Adilson CF, Mariane NN, Chelsea RS, Juan LA, 他
    • Total Pages
      362
    • Publisher
      Bentham Science
    • Related Report
      2015 Annual Research Report
  • [Book] Donald School Textbook of Ultrasound in Obstetrics and Gynecology2016

    • Author(s)
      AboEllail MAM, Hata T.
    • Publisher
      Jaypee Brothers Medical Publishers
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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