| Project/Area Number |
25462563
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nagasaki University |
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Principal Investigator |
MASUZAKI Hideaki 長崎大学, 医歯薬学総合研究科(医学系), 教授 (00173740)
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| Co-Investigator(Kenkyū-buntansha) |
MIURA Kiyonori 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (00363490)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 産婦人科 / 常位胎盤早期剥離 / 血漿 / RNA / 胎盤 / 分子マーカー / microRNA / 母体血漿 / C19MC |
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| Outline of Final Research Achievements |
The median concentration of plasma cell-free miR-517c in the placental abruption group was 21,672.2 copies/mL, while that in the uncomplicated pregnancy group was 13,452.0 copies/mL (Mann-Whitney U-test, P=0.047). The sensitivity and specificity were 73.3% and 62.5%, respectively. In addition, the positive and negative predictive values were 55.0% and 78.9%, respectively. Plasma cell-free miR-517a and miR-517c levels in the large abruption (degree of abruption;>50 % of placenta) group were significantly higher than in the small abruption (<50%) group (P=0.03 for both miRNAs). In conclusion, the circulating level of cell-free miR-517c in maternal plasma was increased as a consequence of placental abruption, and may be a potential biomedical marker for placental abruption.
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