Circulating levels of pregnancy-associated, placenta-specific microRNAs in pregnant women with placental abruption
Project/Area Number |
25462563
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Obstetrics and gynecology
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Research Institution | Nagasaki University |
Principal Investigator |
MASUZAKI Hideaki 長崎大学, 医歯薬学総合研究科(医学系), 教授 (00173740)
|
Co-Investigator(Kenkyū-buntansha) |
MIURA Kiyonori 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (00363490)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | 産婦人科 / 常位胎盤早期剥離 / 血漿 / RNA / 胎盤 / 分子マーカー / microRNA / 母体血漿 / C19MC |
Outline of Final Research Achievements |
The median concentration of plasma cell-free miR-517c in the placental abruption group was 21,672.2 copies/mL, while that in the uncomplicated pregnancy group was 13,452.0 copies/mL (Mann-Whitney U-test, P=0.047). The sensitivity and specificity were 73.3% and 62.5%, respectively. In addition, the positive and negative predictive values were 55.0% and 78.9%, respectively. Plasma cell-free miR-517a and miR-517c levels in the large abruption (degree of abruption;>50 % of placenta) group were significantly higher than in the small abruption (<50%) group (P=0.03 for both miRNAs). In conclusion, the circulating level of cell-free miR-517c in maternal plasma was increased as a consequence of placental abruption, and may be a potential biomedical marker for placental abruption.
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] Fetal cell-free DNA fraction in maternal plasma is affected by fetal trisomy2017
Author(s)
Suzumori N, Ebara T, Yamada T, Samura O, Yotsumoto J, Nishiyama M, Miura K, Sawai H, Murotsuki J, Kitagawa M, Kamei Y, Masuzaki H, Hirahara F, Saldivar JS, Dharajiya N, Sago H, Sekizawa A
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Journal Title
Journal of Human Genetics
Volume: 印刷中
Pages: 印刷中
Related Report
Peer Reviewed
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[Journal Article] Association of maternal pre-pregnancy weight, weight gain during pregnancy, and smoking with small-for-gestational-age infants in Japan2016
Author(s)
Akahoshi E, Arima K, Miura K, Nishimura T, Abe Y, Yamamoto N, Oishi K, Masuzaki H, Aoyagi K
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Journal Title
Early Human Development
Volume: 92
Pages: 33-36
Related Report
Peer Reviewed
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[Journal Article] Circulating levels of maternal plasma cell-free miR-21 are associated with maternal body mass index and neonatal birth weight2015
Author(s)
Miura K, Higashijima A, Hasegawa Y, Abe S, Miura S, Fuchi N, Murakami Y, Kinoshita A, Yoshida A, Kaneuchi M, Yoshiura KI, Masuzaki H
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Journal Title
Prenatal Diagnosis
Volume: 35
Pages: 509-511
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Effect of labor on plasma concentrations and postpartum clearance of cell-free, pregnancy-associated, placenta-specific microRNAs2015
Author(s)
Morisaki S, Miura K, Higashijima A, Abe S, Miura S, Hasegawa Y, Yoshida A, Kaneuchi M, Yoshiura KI, Masuzaki H
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Journal Title
Prenatal Diagnosis
Volume: 35
Pages: 44-50
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Predominantly placenta-expressed mRNAs in maternal plasma as predictive markers for twin-twin transfusion syndrome2014
Author(s)
Miura K, Higashijima A, Miura S, Mishima H, Yamasaki K, Abe S, Hasegawa Y, Kaneuchi M, Yoshida A, Kinoshita A, Yoshiura K, Masuzaki H
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Journal Title
Prenat Diagn
Volume: 34
Pages: 345-349
DOI
Related Report
Peer Reviewed
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[Journal Article] Copy number variation of the antimicrobial-gene, defensin beta 4, is associated with susceptibility to cervical cancer2013
Author(s)
Abe S, Miura K, Kinoshita A, Mishima H, Miura S, Yamasaki K, Hasegawa Y, Higashijima A, Jo O, Sasaki K, Yoshida A, Yoshiura K, Masuzaki H
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Journal Title
J Hum Genet
Volume: 58
Pages: 250-253
DOI
Related Report
Peer Reviewed
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[Journal Article] Characterization of placenta-specific microRNAs in fetal growth restriction pregnancy2013
Author(s)
Higashijima A, Miura K, Mishima H, Kinoshita A, Jo O, Abe S, Hasegawa Y, Miura S, Yamasaki K, Yoshida A, Yoshiura K, Masuzaki H
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Journal Title
Prenat Diagn
Volume: 33
Pages: 214-222
DOI
Related Report
Peer Reviewed
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[Presentation] 周産期におけるゲノム遺伝学2015
Author(s)
三浦清徳、増崎英明
Organizer
第51回日本周産期・新生児医学会学術集会
Place of Presentation
ヒルトンホテル、福岡県福岡市
Year and Date
2015-07-10 – 2015-07-12
Related Report
Invited
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[Presentation] NIPT2015
Author(s)
三浦清徳、増崎英明
Organizer
第62回日本小児保健協会学術集会
Place of Presentation
ブリックホール、長崎県長崎市
Year and Date
2015-06-18 – 2015-06-20
Related Report
Invited
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