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The elucidation of sperm on endometrial function and clinical application to implantation failure

Research Project

Project/Area Number 25462565
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionOita University

Principal Investigator

Kawano Yasushi  大分大学, 医学部, 准教授 (40274758)

Co-Investigator(Kenkyū-buntansha) NARAHARA HISASHI  大分大学, 医学部産科婦人科, 教授 (60211447)
NASU KAEI  大分大学, 医学部地域医療支援システム産婦人科分野, 教授 (30274757)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords子宮内膜 / 着床 / PAR
Outline of Final Research Achievements

To investigate the effect of sperm on endometrial function, the kinase activation via protease-activated receptor (PAR)-2 in endothelial epithelial cells (EECs) and endometrial stromal cells (ESCs) were investigated. Following stimulation by sperm and the PAR-2 agonist, the mitogen-activated protein kinase (MAPK) activity such as extracellular signal-regulated kinase (ERK)-1/2, p38, c-Jun N-terminal kinase (JNK), and glycogen synthase kinase (GSK)-3 were activated, and these signals were inhibited by the PAR-2 antagonist. From our data, the results suggest that sperm induces activation of the MAPK system via PAR-2, leading to the modulation of endometrial function.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2015 2013 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Invited: 1 results)

  • [Journal Article] The possible role for AMP-activated protein kinase (AMPK) by metformin and AICAR in granulosa cells.2015

    • Author(s)
      Kai Y, Kawano Y, Yamamoto H, Narahara H.
    • Journal Title

      Rerod Biol & Endocrinol

      Volume: 13 Issue: 1 Pages: 27-27

    • DOI

      10.1186/s12958-015-0023-2

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 子宮内膜間質細胞の脱落膜化におけるprotease activated receptor-1 (PAR-1) を介した妊娠維持への細胞内情報伝達経路における検討2015

    • Author(s)
      後藤 香里、河野 康志、河邉 史子、宇津宮隆史、楢原 久司
    • Organizer
      第33回日本生殖免疫学会
    • Place of Presentation
      熊本県民交流館パレア【熊本県熊本市)
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 不妊症に対する外科的治療法の最前線 子宮腔内病変に対する妊孕性温存を目指した治療戦略2013

    • Author(s)
      河野康志
    • Organizer
      第58回日本生殖医学会
    • Place of Presentation
      神戸市
    • Related Report
      2013 Research-status Report
  • [Presentation] 子宮鏡下手術の最近の話題 ~子宮腔内病変に対する治療戦略~

    • Author(s)
      河野康志
    • Organizer
      宮崎県北産婦人科医会
    • Place of Presentation
      延岡市
    • Related Report
      2013 Research-status Report
    • Invited

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Published: 2014-07-25   Modified: 2019-07-29  

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