Procalcitonin Levels in Umbilical Venous Blood: Association between Chorioamnionitis Severity and Neonatal Outcome
| Project/Area Number |
25462566
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山口 昌俊 宮崎大学, 医学部, 講師 (90174630)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | プロカルシトニン / 絨毛膜羊膜炎 / 新生児敗血症 / 新生児予後 / 胎盤 / 絨毛膜用膜炎 |
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| Outline of Final Research Achievements |
Procalcitonin (PCT) helps identify or rule out severe bacterial infection in adult. It provides a relatively high degree of certainty in the differential diagnosis of sepsis, severe sepsis or septic shock in adult. The purpose of this study was to assess umbilical PCT level in predicting chorioamnionitis. As a result, PCT levels in the umbilical blood reflect the severity of CAM and are associated with neonatal outcomes such as neonatal sepsis, neonatal death, and severe IVH. However, umbilical PCT level elevated in the case of hypoxic insult in utero. Furthermore, umbilical PCT level showed the mild elevation in chorioamnionitis caused by fungal infection. When PCT level is used as a biomarker for diagnosis chorioamnionitis, we should pay attention to its interpreting.
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Report
(4 results)
Research Products
(8 results)
