In vivo functional analysis of cell fusion suppressor : Suppressyn
| Project/Area Number |
25462567
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
Sugimoto Jun 琉球大学, 医学(系)研究科(研究院), 助教 (10315476)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | サプレシン / 細胞融合抑制 / 絨毛初代培養細胞 / 内在性レトロウイルス / 胎盤 / シンシチン / 細胞融合 |
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| Outline of Final Research Achievements |
Suppressyn is one of the first human proteins to be identified that inhibits cell-cell fusion. We have developed an efficient method for isolation and culture of primary trophoblast cells that allows the study of suppressyn ex vivo. In addition, murine placenta RNAseq expression analysis was used to identify potential mouse suppressyn equivalents. Expression of the four candidate transcripts was confirmed in murine placentas, and functional analysis of these is currently in progress. Our results may help to better define an in vivo role for suppressyn in normal human placental development.
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Report
(3 results)
Research Products
(4 results)
