| Project/Area Number |
25462570
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Yokohama City University |
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Principal Investigator |
HIRAHARA Fumiki 横浜市立大学, 医学研究科, 客員教授 (30201734)
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| Co-Investigator(Kenkyū-buntansha) |
榊原 秀也 横浜市立大学, 附属市民総合医療センター, 教授 (60235140)
浜之上 はるか 横浜市立大学, 附属病院, 講師 (90573759)
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| Co-Investigator(Renkei-kenkyūsha) |
HAMANOUE Haruka 横浜市立大学, 附属病院, 講師 (90573759)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 葉酸 / 先天異常 / 卵成熟 / 発生異常 / 葉酸摂取妊婦 / 妊婦摂取 / 受精，卵成熟 / 催奇形性 / 生殖 / 発生 / 胚 / 遺伝子 |
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| Outline of Final Research Achievements |
Since 2000, preconceptional folic acid supplementation has been recommended in Japan. In Japan, lack of active campaign and attitude of women for folic acid intake has retained behind situation as compared to western countries. In addition, the prevalence of neural tube defects such as spina bifida still showed high incidence (spina bifida; more than 5 in 10000 births) while around only 20% of pregnant women take preconceptional folic acid supplementation.In vitro fertilization study reveals that the folic acid administration demonstrated some defensive role against reactive oxygen species (ROS) such as hydrogen peroxide.The benefits of folic acid intake are not well publicised in Japan and further promotional efforts are thus warranted.
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