| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
As for embryonic factors, the frequency of normal embryonic karyotypes significantly increases with the number of previous abortions and a normal karyotype in a previous pregnancy is a predictor of subsequent miscarriage Although a currently prevailing hypothesis is that recurrent miscarriage may be a polygenetic disorder associated with both genetic and environmental determinants, it may be possible that the condition develops as a single-gene disorder. We found that the c.657T>C mutation of human SYCP3 gene may not be associated with recurrent miscarriage in Japanese. The FXII gene was found to be one of the significant susceptibility genes for miscarriage. However, the clinical influence of the FXII CT genotype or Protein S deficiency/Tokushima mutation data might be relatively small, because the presence/absence of this genotype did not have any predictive value for the subsequent pregnancy outcome.
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