The relationship between endometrial stem cells and epithelial-mesenchymal transfer on the development of endometriosis.
| Project/Area Number |
25462574
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Tetsuo 慶應義塾大学, 医学部, 准教授 (10209702)
UCHIDA Hiroshi 慶應義塾大学, 医学部, 専任講師 (90286534)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 子宮内膜症 / 子宮内膜幹細胞 / 上皮間葉転換（EMT） / Side Population / W5C5 / Side Population W5C5 / Side Population W5C5 |
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| Outline of Final Research Achievements |
Flow cytometry analysis revealed that endometrial side population (SP) cells, CD146+PDGFRβ+ cells and W5C5+ cells were different populations, but these populations overlapped partially. The migration activity of endometrial cells and endometrial SP cells was demonstrated, and the activity was suppressed by an epithelial-mesenchymal transfer inhibitor. We are trying to show this inhibitory effect in vivo using our mouse model.
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Report
(3 results)
Research Products
(39 results)
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[Journal Article] CD34 and CD49f double-positive and lineage marker-negative cells isolated from human myometrium exhibit stem cell-like properties involved in pregnancy-induced uterine remodeling.2015
Author(s)
Ono M, Kajitani T, Uchida H, Arase T, Oda H, Uchida S, Ota K, Nagashima T, Masuda H, Miyazaki K, Asada H, Hida N, Mabuchi Y, Morikawa S, Ito M, Bulun SE, Okano H, Matsuzaki Y, Yoshimura Y, Maruyama T
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Journal Title
Biol Reprod
Volume: 93巻
Issue: 2
Pages: 1-9
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] System amino acid transporter SNAT2 shows subtype-specific affinity for betaine and hyperosmotic inducibility in placental trophoblasts.2014
Author(s)
Nishimura T, Yagi R, Usuda M, Oda K, Yamazaki M, Suda S, Takahashi Y, Okazaki F, Sai Y, Higuchi, K, Maruyama T, Tomi M, Nakashima E
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Journal Title
Biochim Biophys Acta.
Volume: VOL. 1838
Issue: 5
Pages: 1306-12
DOI
Related Report
Peer Reviewed
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[Presentation] Non-invasive and real-time assessment of peritoneal lesions generated from human endometrial cell transplants locally accumulated by magnetic force in immunodeficient mice.2015
Author(s)
Tetsuo Maruyama, Hirotaka Masuda, Naoko Hida, Hideyuki Oda, Kaoru Miyazaki, Miki Fumie, Hanako Hihara, Kuniaki Ota, Hiroshi Uchida, Mamoru Tanaka
Organizer
31th Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE).
Place of Presentation
Lisbon, Portugal.
Year and Date
2015-06-14
Related Report
Int'l Joint Research
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