| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
In this study, we sought to develop novel methods for ovarian follicle stimulation by identifying local factors important for early follicle growth and subsequent analyses of its molecular mechanisms. Based on comprehensive DNA microarray analyses, we determined the candidates of ligand/receptor pairs expressing in early stage of ovarian follicles and addressed their roles in follicle growth using murine in vitro and in vivo experiments. Among the candidates, we found C-type natriuretic peptide and CCN growth factor as factors for growth of secondary follicles onward, whereas R-spondin2 as a factor for growth of primary follicles onward.
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