Associations between human papillomavirus (HPV) types and clinical features of invasive cervical cancer

• Project/Area Number: 25462585
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: University of Tsukuba
• Principal Investigator: MATSUMOTO Koji 筑波大学, 医学医療系, 准教授 (30302714)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 子宮頸癌 / HPV / CIN / LSIL / HSIL / HLA / colposcopy / cytology / 子宮頸がん / ヒトパピローマウイルス

Outline of Final Research Achievements

In the present study, HPV type-specific data from 260 women with FIGO Ib1-IVB cervical cancer suggested that HPV16 positivity may be an independent predictor of favorable survival in invasive cervical cancer. This finding is prepared for submission. Also, we have reported the following findings: 1) At least two colposcopy-directed biopsies should be taken for histological diagnosis. 2) Of women with LSIL cytology, those testing negative for at least eight of the highest-risk types of HPV (HPV16/18/31/33/35/45/52/58) may not need immediate colposcopy and biopsy. 3) HLA Clas II DRB1*1302 allele may have a protective effect against progression from CIN1 to CIN2/3 and 4) HPV testing was more sensitive than cytology in detecting posttreatment CIN 2+, and had an equal specificity compared with cytology.

Research Products

• [Journal Article] Posttreatment human papillomavirus testing for residual or recurrent high-grade cervical intra-epithelial neoplasia: a pooled analysis (2016)
  • Author(s): Onuki M, Matsumoto K, Sakurai M, Ochi H, Minaguchi T, Satoh T, Yoshikawa H.
  • Journal Title: Journal of Gynecologic Oncology Volume: 27 Issue: 1
  • DOI: 10.3802/jgo.2016.27.e3
  • NAID: 120007135489
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Human leukocyte antigen class II DRB1*1302 allele protects against cervical cancer: At which step of multistage carcinogenesis? (2015)
  • Author(s): Koji Matsumoto, Hiroo Maeda, Akinori Oki, Naoyoshi Takatsuka, Toshiharu Yasugi, Reiko Furuta, Ranko Hirata, Akira Mitsuhashi, Kei Kawana, Takuma Fujii, Takashi Iwata, Yasuo Hirai, Masatoshi Yokoyama, Nobuo Yaegashi, Yoh Watanabe, Yutaka Nagai, Hiroyuki Yoshikawa
  • Journal Title: Cancer Science Volume: 106(10) Issue: 10 Pages: 1448-1454
  • DOI: 10.1111/cas.12760
  • Peer Reviewed / Open Access
• [Journal Article] HPV genotyping for triage of women with abnormal cervical cancer screening results: a multicenter prospective study (2015)
  • Author(s): Yuko Nakamura, Koji Matsumoto, Toyomi Satoh, Ken Nishide, Akiko Nozue, Koji Shimabukuro, Seiichi Endo, Kimihiro Nagai, Akinori Oki, Hiroyuki Ochi, Yukio Morishita, Masayuki Noguchi, Hiroyuki Yoshikawa
  • Journal Title: International Journal of Clinical Oncology Volume: 印刷中 Issue: 5 Pages: 974-981
  • DOI: 10.1007/s10147-015-0789-4
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Optimizing biopsy procedures during colposcopy for women with abnormal cervical cancer screening results: a multicenter prospective study. (2015)
  • Author(s): Nakamura Y, Matsumoto K, Satoh T, Nishide K, Nozue A, Shimabukuro K, Endo S, Nagai K, Oki A, Minaguchi T, Morishita Y, Noguchi M, Yoshikawa H.
  • Journal Title: Int J Clin Oncol. Volume: 20(3) Issue: 3 Pages: 579-585
  • DOI: 10.1007/s10147-014-0739-6
  • Peer Reviewed / Open Access
• [Presentation] CIN進展リスクの新たな指標の探索と子宮頸癌における病態バイオマーカーとしてのHPVタイプ (2015)
  • Author(s): 松本光司
  • Organizer: 第67回日本産科婦人科学会学術講演会
  • Place of Presentation: 横浜
  • Year and Date: 2015-04-09
• [Presentation] CIN進展リスクの新たな指標の探索と 子宮頸癌における病態バイオマーカーとしてのHPVタイプ (2015)
  • Author(s): 松本光司
  • Organizer: 第67回日本産科婦人科学会
  • Place of Presentation: パシフィコ横浜