Bioinformatic analysis and functional genomics of refractory endometrial cancer subtype

• Project/Area Number: 25462589
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Kyoto University
• Principal Investigator: Baba Tsukasa 京都大学, 医学(系)研究科(研究院), 講師 (60508240)
• Co-Investigator(Kenkyū-buntansha): Konishi Ikuo 京都大学大学院医学研究科, 器官外科学・婦人科学産科学, 教授 (90192062)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 子宮体癌 / 漿液癌 / ドライバー / マイクロアレイ / 漿液性癌 / 転移 / 子宮内膜

Outline of Final Research Achievements

Through bioinformatic analysis and functional genomics of refractory endometrial cancer subtypes, STAT1 pathway in serous carcinoma as well as GPR54-metastin axis in low grade endometrioid adenocarcinoma were detected as key molecules of tumor progression and new potent therapeutic targets. Based on these findings, development of molecular targeting therapy are in preparation as several international cooperative researches.

Research Products

• [Int'l Joint Research] MD Anderson Cancer Center(米国)
• [Int'l Joint Research] Baylor College of Medicine(米国)
• [Int'l Joint Research] University of Southern California/University of Pittsburgh/University of Kentucky(米国)
• [Journal Article] Significance of histologic pattern of carcinoma and sarcoma components on survival outcomes of uterine carcinosarcoma. (2016)
  • Author(s): Matsuo K, Takazawa Y, Ross MS, Elishaev E, Podzielinski I, Yunokawa M, Sheridan TB, Bush SH, Klobocista MM, Blake EA, Takano T, Matsuzaki S, Baba T, et al.
  • Journal Title: Ann Oncol. Volume: 27 Issue: 7 Pages: 1257-1266
  • DOI: 10.1093/annonc/mdw161
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 【婦人科腹腔鏡手術の適応と限界を考える】 がん、再発がん (2016)
  • Author(s): 馬場 長、安彦 郁、北村幸子、堀江昭史、松村謙臣、山口 建、近藤英治、濱西潤三、伊藤美幸、小西郁生
  • Journal Title: 産婦人科の実際 Volume: 65 Pages: 141-6
• [Journal Article] Time interval between endometrial biopsy and surgical staging for type I endometrial cancer: association between tumor characteristics and survival outcome. (2015)
  • Author(s): Matsuo K, Opper NR, Ciccone MA, Garcia J, Tierney KE, Baba T, Muderspach LI, Roman LD.
  • Journal Title: Obstet Gynecol. Volume: 125 Issue: 2 Pages: 424-33
  • DOI: 10.1097/aog.0000000000000636
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Subendometrial enhancement and peritumoral enhancement for assessing endometrial cancer on dynamic contrast enhanced MR imaging. (2015)
  • Author(s): Fujii S, Kido A, Baba T, Fujimoto K, Daido S, Matsumura N, Konishi I, Togashi K.
  • Journal Title: Eur J Radiol Volume: 84 Issue: 4 Pages: 581-589
  • DOI: 10.1016/j.ejrad.2015.01.004
  • Peer Reviewed
• [Journal Article] 【ゲノム時代の婦人科がん診療を展望する-がんの個性に応じたpersonalizationへの道】 子宮体がん 子宮体部漿液性腺癌のゲノム解析と新治療開発 (2015)
  • Author(s): 馬場 長、小西郁生
  • Journal Title: 臨床婦人科産科 Volume: 69 Pages: 81-7
• [Journal Article] 【子宮内膜癌治療の最前線】 進行、再発子宮内膜癌に対する治療戦略 (2015)
  • Author(s): 馬場 長、水野 林、小西郁生
  • Journal Title: 産婦人科の実際 Volume: 64 Pages: 651-8
• [Journal Article] Menstrual cyclic change of metastin/GPR54 in endometrium. (2014)
  • Author(s): BabaT, Kang HS, Hosoe Y, Kharma B, Aniko K, Matsumura N, Hamanishi J, Yamaguchi K, Yoshioka Y, Koshiyama M, N\Mandai M, Murphy SK, Konishi I
  • Journal Title: Med Mol Morphol Volume: 08 Issue: 2 Pages: 1-9
  • DOI: 10.1007/s00795-014-0081-0
  • Peer Reviewed
• [Journal Article] Humoral hypercalcemia caused by uterine corpus carcinosarcoma consisting of squamous cell carcinoma in its epithelial component. (2014)
  • Author(s): Takamatsu S, Matsumura N, Baba T, Mandai M, Mikami Y, Konishi I.
  • Journal Title: J Obstet Gynaecol Res. Volume: 40 Issue: 1 Pages: 263-7
  • DOI: 10.1111/jog.12136
  • Peer Reviewed
• [Journal Article] Utilization of genomic signatures to identify high efficacy candidate drugs for chemo-refractory endometrial cancers. (2013)
  • Author(s): Kharma B, Baba T, Mandai M, Matsumura N, Murphy SK, Kang HS, Yamanoi K, Hamanishi J, Yamaguchi K, Yoshioka Y, Konishi I.
  • Journal Title: Int J Cancer. Volume: 133 Issue: 9 Pages: 2234-44
  • DOI: 10.1002/ijc.28220
  • Peer Reviewed
• [Journal Article] Clinical Management of Atypical Polypoid Adenomyoma of the Uterus. A Clinicopathological Review of 29 Cases (2013)
  • Author(s): Matsumoto T, Hiura M, Baba T, Ishiko O, Shiozawa T, Yaegashi N, Kobayashi H, Yoshikawa H, Kawamura N, Kaku T
  • Journal Title: Gynecol Oncol Volume: 129(1) Issue: 1 Pages: 54-57
  • DOI: 10.1016/j.ygyno.2012.12.040
  • Peer Reviewed
• [Presentation] 難治性子宮体癌における治療ターゲットの探索 (2015)
  • Author(s): 馬場 長
  • Organizer: 第6回金沢大学学際科学実験センターシンポジウム
  • Place of Presentation: 金沢大学 十全記念スタジオ
  • Year and Date: 2015-11-13
  • Invited
• [Presentation] 高悪性度子宮体癌のドライバー遺伝子はSTAT1か? (2015)
  • Author(s): 馬場 長、Budiman Kharma、曽 翔、姜 賢淑、松村 謙臣、濱西 潤三、安彦 郁、山口 建、村上 隆介、万代 昌紀、David Hunstman、小西 郁生
  • Organizer: 第53回日本癌治療学会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2015-10-29
• [Presentation] 子宮体部癌肉腫はMRIにおける造影不良域が予後因子となる (2015)
  • Author(s): 井上 彩美、山口 建、馬場 長、滝 真奈、安彦 郁、濱西 潤三、吉岡 弓子、越山 雅文、近藤 英治、松村 謙臣、小西 郁生
  • Organizer: 第53回日本癌治療学会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2015-10-29
• [Presentation] Integrative analysis identify STAT1 pathway as an oncogenic driver in Serous Papillary Endometrial Cancers (2015)
  • Author(s): Budiman Kharma, Tsukasa Baba, Xiang Zheng, Noriomi Matsumura, Kaoru Abiko, Ryusuke Murakami, Junzo Hamanishi, Ken Yamaguchi, Masaki Mandai, Ikuo Konishi
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2015-10-08
• [Presentation] Down regulation of STAT1 confers Cisplatin sensitivity in Serous Papillary Endometrial Cancer (2015)
  • Author(s): Xiang Zeng, Budiman Kharma, Tsukasa Baba, Noriomi Matsumura, Kaoru Abiko, Junzo Hamanishi, Ken Yamaguchi, Masafumi Koshiyama, Ikuo Konishi
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2015-10-08
• [Presentation] 難治性子宮体癌における治療ターゲットの探索 (2015)
  • Author(s): 馬場 長、Budiman Kharma、曾 翔、姜 賢淑、松村謙臣、安彦 郁、濱西潤三、山口 建、越山雅文、小西郁生
  • Organizer: 第2回新潟産婦人科シンポジウム
  • Place of Presentation: 新潟大学 有壬記念館
  • Year and Date: 2015-09-14
  • Invited
• [Presentation] 子宮体癌に対する腹腔鏡手術のあるべき姿とは？ (2015)
  • Author(s): 馬場 長、堀江昭史、松村謙臣、安彦 郁、伊藤美幸、山口 建、近藤英治、小西郁生
  • Organizer: 第55回日本産科婦人科内視鏡学会学術講演会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2015-09-10
  • Invited
• [Presentation] STAT1 drives tumor progression in serous papillary endometrial cancer (2015)
  • Author(s): sukasa Baba, Budiman Kharma, Noriomi Matsumura, Junzo Hamanishi, Kaoru Abiko, Ken Yamaguchi, Ikuo Konishi:
  • Organizer: GAP 2015 Conference
  • Place of Presentation: MD Anderson Cancer Center.Houston
  • Year and Date: 2015-04-14
  • Int'l Joint Research
• [Presentation] 子宮体部癌肉腫における脈管侵襲像の病理組織学的検討 (2015)
  • Author(s): 滝 真奈, 馬場 長, 安彦 郁, 松村 謙臣, 濱西 潤三, 山口 建, 越山 雅文, 小西 郁生
  • Organizer: 第67回日本産科婦人科学会学術講演会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2015-04-09
• [Presentation] 術前に「低リスク」と考えられる子宮体癌に対して腹腔鏡手術を行う場合の問題点 (2015)
  • Author(s): 平山 貴裕, 馬場 長, 堀江 昭史, 安彦 郁, 松村 謙臣, 近藤 英治, 山口 建, 濱西 潤三, 吉岡 弓子, 越山 雅文, 小西 郁生
  • Organizer: 第67回日本産科婦人科学会学術講演会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2015-04-09
• [Presentation] STAT1 Pathway Promotes Progression of Serous Papillary Endometrial Cancer (2014)
  • Author(s): Tsukasa Baba, Budiman Kharma, Noriomi Matsumura, Ken Yamaguchi, Junzo Hamanishi, Kaoru Abiko, Ikuo Konishi
  • Organizer: 45th Annual Meeting on Women's Cancer
  • Place of Presentation: Tampa Convention Center(アメリカ合衆国)
• [Presentation] 正常子宮内膜および内膜癌におけるmetastinとその受容体 GPR54の発現について (2013)
  • Author(s): 馬場 長
  • Organizer: 第45回日本臨床分子形態学会
  • Place of Presentation: アクロス福岡(福岡県)
• [Presentation] STAT1 Pathway Promotes Progression and Development of Serous Papillary Endometrial Cancer (2013)
  • Author(s): Budiman Kharma, Tsukasa Baba, Noriomi Matsumura, Hyun Sook Kang, Ryusuke Murakami, Kaoru Abiko, Ken Yamaguchi, Junzo Hamanishi, Masaki Mandai, Ikuo Konishi
  • Organizer: The 3rd biennial meeting of Asia Society of Gynecologic Oncology
  • Place of Presentation: Westin Miyako Hotel(京都府)