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Investigation of new treatment strategy for uterine carcinosarcoma by using cancer tissue originated spheroid

Research Project

Project/Area Number 25462591
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionOsaka University

Principal Investigator

FUJITA MASAMI  大阪大学, 医学(系)研究科(研究院), 招へい准教授 (60303963)

Co-Investigator(Kenkyū-buntansha) Yoshino Kiyoshi  大阪大学, 大学院医学系研究科, 准教授 (90362730)
Ueda Yutaka  大阪大学, 大学院医学系研究科, 助教 (10346215)
Kobayashi Eiji  大阪大学, 大学院医学系研究科, 助教 (50614773)
Kimura Toshihiro  大阪大学, 大学院医学系研究科, 招へい教員 (90584524)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords婦人科腫瘍 / 子宮体部癌内腫 / 子宮体部癌肉腫 / CTOS
Outline of Final Research Achievements

Advanced uterine carcinosarcoma is difficult to cure and the standard treatment is not determined. We searched if we can establish primary culture of uterine carcinosarcoma by cancer tissue-originated spheroid (CTOS) method and if we can use drug screening kit for uterine carcinosarcoma by using CTOS method. One of the results is that we established primary culture of uterine carcinosarcoma by CTOS method. And the other result is that we found we can screen effective drugs for uterine carcinosarcoma by CTOS method and drug screening kit. We could not proceed to animal model. However we showed personalized medicine is also feasible by CTOS methods.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Plasma nlembrane proteonlics identifies bone marrow stromal antigen 2 as a potential therapeutic target in endometrial cancer2013

    • Author(s)
      Yokoyama T, Enomoto T, Serada S, Morimoto A, Matsuzaki S, Ueda Y, Yoshino K, Fujita M, Kyo S, Iwahori K, Fujimoto M, Kimura T, Naka T
    • Journal Title

      Int J Cancer

      Volume: 132(2) Issue: 2 Pages: 472-84

    • DOI

      10.1002/ijc.27679

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Annexin A4-conferred platinum resistance is mediated by the copper transporter ATP7A2013

    • Author(s)
      Matsuzaki, S. Morimoto, A. Serada, S. Yokoyama, T. Kimura, T. Kobayashi, E. Ueda, Y. Yoshino, K. Fujita, M. Enomoto, T. Naka, T. Kimura, T.
    • Organizer
      The 104th Annual Meeting American Association for Cancer Research
    • Place of Presentation
      Washington DC, U.S.A.
    • Related Report
      2013 Research-status Report
  • [Presentation] Annexin A4の発現は銅のトランスポーターでありプラチナの排出に関与すると知られるATP7Aを介して,耐性獲得に関与する2013

    • Author(s)
      松崎慎哉 森本晶子 横山拓平 小林栄仁 木村敏啓 上田豊 吉野潔 藤田征巳 榎本隆之 木村正 仲哲治
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] プラチナ耐性に関与するAnnexin A4の機能領域解析2013

    • Author(s)
      森本晶子 榎本隆之 松崎慎哉 横山拓平 小林栄仁 木村敏啓 上田豊 吉野潔 藤田征巳 仲哲治 木村正
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] Annexin A4の機能領域解析を用いた癌細胞プラチナ耐性機構の解明2013

    • Author(s)
      森本晶子 榎本隆之 世良田聡 木村敏啓 上田豊 藤田征巳 仲哲治 木村正
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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