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PITX1 expression and the telomerase control in an endometrial menstrual cycle and carcinogenic process

Research Project

Project/Area Number 25462593
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKobe University

Principal Investigator

Ebina Yasuhiko  神戸大学, 医学研究科, 准教授 (90322809)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords子宮内膜 / 子宮体癌 / テロメレース / 生殖 / 発癌
Outline of Final Research Achievements

PITX1 protein was expressed in the tumor of the case with poorly-differentiated uterine cancer. However, no expression of PITX1 in more than 90% of the case with uterine cancer. Therefore, this might be associated with telomerase overexpression. PITX1 expression was detected in normal endometrium. Specific relationships could not be obtained regarding to menstrual cycle and carcinogenesis. I keep on analyzing the data that can be got throughout this period.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (10 results)

All 2017 2016 2015

All Journal Article (10 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 10 results,  Acknowledgement Compliant: 3 results,  Open Access: 1 results)

  • [Journal Article] Natural killer cell activity in women with recurrent miscarriage: Etiology and pregnancy outcome2017

    • Author(s)
      Yasuhiko Ebina, Yukari Nishino, Masashi Deguchi, Yoko Maesawa, Yuki Nakashima, Hideto Yamada
    • Journal Title

      Journal of Reproductive Immunology

      Volume: 120 Pages: 42-47

    • DOI

      10.1016/j.jri.2017.04.005

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] PCR tests for uterine cervical secretion are promising noninvasive methods for predicting congenital cytomegalovirus infection2017

    • Author(s)
      Kenji Tanimura, Yasuhiko Ebina, Hideto Yamada
    • Journal Title

      Expert Review of Molecular Diagnostics

      Volume: 2017 Issue: 6 Pages: 1-3

    • DOI

      10.1080/14737159.2017.1318068

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A pregnant woman with a surgical site infection after mesh repair of an abdominal wall incisional hernia: a case report2017

    • Author(s)
      Kana Ozaki, Kenji Tanimura, Yasuhiko Ebina, Kiyonori Kanemitsu, Hideto Yamada
    • Journal Title

      Journal of Medical Case Reports

      Volume: 11 Issue: 1 Pages: 1-3

    • DOI

      10.1186/s13256-017-1217-3

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Prediction of Congenital Cytomegalovirus Infection in High-Risk Pregnant Women2017

    • Author(s)
      Kenji Tanimura, Shinya Tairaku, Yasuhiko Ebina, Ichiro Morioka, Satoshi Nagamata, Kana Deguchi, Mayumi Morizane, Masashi Deguchi, Toshio Minematsu, Hideto Yamada
    • Journal Title

      Clinical Infectious Diseases

      Volume: 64 Issue: 2 Pages: 159-165

    • DOI

      10.1093/cid/ciw707

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Divergence of helper, cytotoxic, and regulatory T cells in the decidua from miscarriage2016

    • Author(s)
      Ebina Y, Shimada S, Deguchi M, Maesawa Y, Iijima N, Yamada H.
    • Journal Title

      Am J Reprod Immunol.

      Volume: 76 Issue: 3 Pages: 199-204

    • DOI

      10.1111/aji.12546

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Case of uterine leiomyosarcoma with long-term disease control by Pazopanib2016

    • Author(s)
      Satoshi Nagamata, Yasuhiko Ebina, Yumika Yamano, Takeo Miyamoto, Mitsuhiro Nishijima, Hideto Yamada
    • Journal Title

      Kobe J Med Sci

      Volume: 62

    • NAID

      120005866879

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Protein S deficiency complicated pregnancy in women with recurrent pregnancy loss2016

    • Author(s)
      Nanae Shinozaki, Yasuhiko Ebina, Masashi Deguchi, Kenji Tanimura, Mayumi Morizane, Hideto Yamada
    • Journal Title

      Gynecological Endocrinology

      Volume: 32 Issue: 8 Pages: 672-374

    • DOI

      10.3109/09513590.2016.1152239

    • NAID

      120005893329

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Rapid increase of serum IgG avidity index in women with congenital cytomegalovirus infection2015

    • Author(s)
      Ebina Y, Minematsu T, Morioka I, Deguchi M, Tairaku S, Tanimura K, Sonoyama A, Nagamata S, Morizane M, Yamada H
    • Journal Title

      J Clin Virol

      Volume: 66 Pages: 44-47

    • DOI

      10.1016/j.jcv.2015.03.002

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Low levels of plasma protein S, protein C and coagulation factor XII during early pregnancy and adverse pregnancy outcome.2015

    • Author(s)
      Ebina Y, Ieko M, Naito S, Kobashi G, Deguchi M, Minakami H, Atsumi T, Yamada H.
    • Journal Title

      Thromb Haemost.

      Volume: 114 Issue: 07 Pages: 65-69

    • DOI

      10.1160/th14-11-0928

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Human recombinant H2 relaxin induces AKT and GSK3β phosphorylation and HTR-8/SVneo cell proliferation2015

    • Author(s)
      Astuti Y, Nakabayashi K, Deguchi M, Ebina Y, Yamada H
    • Journal Title

      Kobe J Med Sci

      Volume: 61

    • NAID

      120005617327

    • Related Report
      2015 Research-status Report
    • Peer Reviewed

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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