PITX1 expression and the telomerase control in an endometrial menstrual cycle and carcinogenic process

• Project/Area Number: 25462593
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Kobe University
• Principal Investigator: Ebina Yasuhiko 神戸大学, 医学研究科, 准教授 (90322809)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 子宮内膜 / 子宮体癌 / テロメレース / 生殖 / 発癌

Outline of Final Research Achievements

PITX1 protein was expressed in the tumor of the case with poorly-differentiated uterine cancer. However, no expression of PITX1 in more than 90% of the case with uterine cancer. Therefore, this might be associated with telomerase overexpression. PITX1 expression was detected in normal endometrium. Specific relationships could not be obtained regarding to menstrual cycle and carcinogenesis. I keep on analyzing the data that can be got throughout this period.

Research Products

• [Journal Article] Natural killer cell activity in women with recurrent miscarriage: Etiology and pregnancy outcome (2017)
  • Author(s): Yasuhiko Ebina, Yukari Nishino, Masashi Deguchi, Yoko Maesawa, Yuki Nakashima, Hideto Yamada
  • Journal Title: Journal of Reproductive Immunology Volume: 120 Pages: 42-47
  • DOI: 10.1016/j.jri.2017.04.005
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] PCR tests for uterine cervical secretion are promising noninvasive methods for predicting congenital cytomegalovirus infection (2017)
  • Author(s): Kenji Tanimura, Yasuhiko Ebina, Hideto Yamada
  • Journal Title: Expert Review of Molecular Diagnostics Volume: 2017 Issue: 6 Pages: 1-3
  • DOI: 10.1080/14737159.2017.1318068
  • Peer Reviewed
• [Journal Article] A pregnant woman with a surgical site infection after mesh repair of an abdominal wall incisional hernia: a case report (2017)
  • Author(s): Kana Ozaki, Kenji Tanimura, Yasuhiko Ebina, Kiyonori Kanemitsu, Hideto Yamada
  • Journal Title: Journal of Medical Case Reports Volume: 11 Issue: 1 Pages: 1-3
  • DOI: 10.1186/s13256-017-1217-3
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Prediction of Congenital Cytomegalovirus Infection in High-Risk Pregnant Women (2017)
  • Author(s): Kenji Tanimura, Shinya Tairaku, Yasuhiko Ebina, Ichiro Morioka, Satoshi Nagamata, Kana Deguchi, Mayumi Morizane, Masashi Deguchi, Toshio Minematsu, Hideto Yamada
  • Journal Title: Clinical Infectious Diseases Volume: 64 Issue: 2 Pages: 159-165
  • DOI: 10.1093/cid/ciw707
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Divergence of helper, cytotoxic, and regulatory T cells in the decidua from miscarriage (2016)
  • Author(s): Ebina Y, Shimada S, Deguchi M, Maesawa Y, Iijima N, Yamada H.
  • Journal Title: Am J Reprod Immunol. Volume: 76 Issue: 3 Pages: 199-204
  • DOI: 10.1111/aji.12546
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A Case of uterine leiomyosarcoma with long-term disease control by Pazopanib (2016)
  • Author(s): Satoshi Nagamata, Yasuhiko Ebina, Yumika Yamano, Takeo Miyamoto, Mitsuhiro Nishijima, Hideto Yamada
  • Journal Title: Kobe J Med Sci Volume: 62
  • NAID: 120005866879
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Protein S deficiency complicated pregnancy in women with recurrent pregnancy loss (2016)
  • Author(s): Nanae Shinozaki, Yasuhiko Ebina, Masashi Deguchi, Kenji Tanimura, Mayumi Morizane, Hideto Yamada
  • Journal Title: Gynecological Endocrinology Volume: 32 Issue: 8 Pages: 672-374
  • DOI: 10.3109/09513590.2016.1152239
  • NAID: 120005893329
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Rapid increase of serum IgG avidity index in women with congenital cytomegalovirus infection (2015)
  • Author(s): Ebina Y, Minematsu T, Morioka I, Deguchi M, Tairaku S, Tanimura K, Sonoyama A, Nagamata S, Morizane M, Yamada H
  • Journal Title: J Clin Virol Volume: 66 Pages: 44-47
  • DOI: 10.1016/j.jcv.2015.03.002
  • Peer Reviewed
• [Journal Article] Low levels of plasma protein S, protein C and coagulation factor XII during early pregnancy and adverse pregnancy outcome. (2015)
  • Author(s): Ebina Y, Ieko M, Naito S, Kobashi G, Deguchi M, Minakami H, Atsumi T, Yamada H.
  • Journal Title: Thromb Haemost. Volume: 114 Issue: 07 Pages: 65-69
  • DOI: 10.1160/th14-11-0928
  • Peer Reviewed
• [Journal Article] Human recombinant H2 relaxin induces AKT and GSK3β phosphorylation and HTR-8/SVneo cell proliferation (2015)
  • Author(s): Astuti Y, Nakabayashi K, Deguchi M, Ebina Y, Yamada H
  • Journal Title: Kobe J Med Sci Volume: 61
  • NAID: 120005617327
  • Peer Reviewed