| Project/Area Number |
25462595
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAGASAKA TAKESHI 岡山大学, 大学病院, 講師 (30452569)
UNEDA YUZOU 岡山大学, 大学病院, 助教 (10573735)
SUNO MANABU 岡山大学, 医療教育統合開発センター, 准教授 (20621189)
HIRAMATSU YUJI 岡山大学, 医歯薬学総合研究科, 教授 (80218817)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 子宮体癌 / LS / MSI / MMR / Epigenetic / 分子生物学的研究 / KRAS / BRAF / PIK3CA / PIK3R1 |
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| Outline of Final Research Achievements |
We developed a new Lynch syndrome screening strategy for endometrial cancer by detection of 1)MSI using a panel of 4 mononucleotide microsatellite markers (BAT26, NR21, NR27, and CAT25) 2) protein expression for MLH1, MSH2, PMS2, MSH6 using immunohistochemical (IHC) staining, and 3) MLH1 promoter CpG island using PCR.
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