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Multicenter randomized Phase III Trial of concurrent chemoradiotherapy(CCRT) with Cisplatin versus CCRT with Cisplatin and Paclitaxel for locally uterine cervix adenocarcinoma

Research Project

Project/Area Number 25462598
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionUniversity of the Ryukyus

Principal Investigator

Nagai Yutaka  琉球大学, 医学(系)研究科(研究院), 准教授 (70305209)

Co-Investigator(Kenkyū-buntansha) 戸板 孝文  琉球大学, 医学(系)研究科(研究院), 客員教授 (30237036)
稲嶺 盛彦  琉球大学, 医学(系)研究科(研究院), 講師 (90437989)
久高 亘  琉球大学, 医学部附属病院, 講師 (50529336)
大山 拓真  琉球大学, 医学(系)研究科(研究院), 助教 (40713350)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords子宮頸部腺癌 / 同時化学放射線療法 / 多施設共同研究 / 第Ⅲ相試験 / シスプラチン / パクリタキセル / 観察研究 / 第III相試験
Outline of Final Research Achievements

Concurrent chemoradiotherapy (CCRT) using cisplatin is gold-standard treatment for advanced carcinoma of the uterine cervix. Although it is unclear whether cisplatin-based concurrent chemoradiotherapy has the same effect on adenocarcinoma as on squamous cell carcinoma.To evaluate safety and efficacy of CCRT with cisplatin (CCRT-P) vs CCRT with cisplatin and paclitaxel (CCRT-TP) for locally uterine cervix adenocarcinoma, we conducted a pahse III study for CCRT-P vs CCRT-TP. Because of poor enrollment for this study, we had to decide early termination of this trial. Immediately after this, We planned a national survey by patient who received CCRT for locally uterine cervix adenocarcinoma at this time. The altenative study showed that CCRT-TP achieved much better overall survival for adenocarcinoma of the uterine cervix.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (6 results)

All Other

All Remarks (6 results)

  • [Remarks] 臨床研究 3. 症例集積終了、経過観察中の臨床研究 子宮頸がん JGOG1074

    • URL

      http://www.jgog.gr.jp/kaiin/kaiin2/enforcement_outline/enforcement_outline.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 臨床研究 3. 症例集積終了、経過観察中の臨床研究 子宮頸がん JGOG1074 試験中止のお知らせ

    • URL

      http://www.jgog.gr.jp/kaiin/kaiin2/enforcement_outline/jgog1074/jgog1074.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 現在実施中の調査研究 JGOG1080Sについて

    • URL

      http://www.jgog.gr.jp/clinical_testing/clinical_testing.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 臨床研究 1. 症例集積中の臨床研究 子宮頸がん JGOG 1080S

    • URL

      http://www.jgog.gr.jp/kaiin/kaiin2/enforcement_outline/enforcement_outline.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 臨床研究 JGOG 1080S

    • URL

      http://www.jgog.gr.jp/kaiin/kaiin2/enforcement_outline/jgog1080s/JGOG1080s.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 現在企画中の臨床研究/調査研究

    • URL

      http://www.jgog.gr.jp/kaiin/kaiin2/enforcement_outline/enforcement_outline.html

    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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