| Project/Area Number |
25462600
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Ibaraki Prefectural University of Health Science |
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Principal Investigator |
Yamaguchi Naoto 茨城県立医療大学, 保健医療学部, 教授 (40239900)
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| Co-Investigator(Kenkyū-buntansha) |
ARAI Jesmin (ARAI Subrina) 筑波大学, 医学医療系, 助教 (60374261)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 糖尿病 / 血管内皮増殖因子 / エストロゲン受容体 / 閉経 / 心不全 / マウス / 心臓組織 / 閉経後 / VEGF / 微小循環異常 |
|---|
| Outline of Final Research Achievements |
We have previously demonstrated that vascular endothelial growth factor (VEGF) is critical for heart tissue (coronary) microvascular angiogenesis in diabetes. Here we attempt to elucidate the effects of estrogen and its specific receptor (ER) subtype in heart tissue VEGF pathways and microvascular angiogenesis using 15-week female mice that are either wild-type (WT), lack of ER alpha (ER alpha KO) or beta (ER beta KO), all of them have diabetes induced by streptozotocin. Cardiac function was reduced and VEGF expression was down-regulated in both ER alpha KO and ER beta KO mice, especially in ER alpha KO mice, compared to WT. These findings suggest that ER alpha are predominantly involved in the pathogenesis of diabetic heart failure through down-regulation of tissue VEGF pathway.
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