The origin of ovarian clear cell carcinoma and endometrioid carcinoma malignant transformation from endometriosis

• Project/Area Number: 25462611
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Keio University
• Principal Investigator: Akahane Tomoko 慶應義塾大学, 医学部, 特任助教 (40398699)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 卵巣癌 / 発癌メカニズム

Outline of Final Research Achievements

A recent study, ovarian cancer is not single character, carcinogenesis original cell and carcinogenesis mechanisms have been elucidated to be different by histopathological type. This study is to clarify the carcinogenic mechanism of ovarian cancer from endometriosis. Analyzed of gene mutation and protein expression in endometriosis co-existence clear cell carcinoma and endometrial cancer. TP53 gene mutations were similar to the characteristics of the serous cancer. These results may suggest that ovarian cancer of origin from endometriosis were mixed serous cancer of origin from fallopian tube epithelial cell.

Research Products

• [Journal Article] Polymorphisms of estrogen metabolism-related genes ESR1, UGT2B17, and UGT1A1 are not associated with osteoporosis in artificial menopausal Japanese women. (2015)
  • Author(s): Yokota M, Hirasawa A, Makita K, Akahane T, Sakai K, Makabe T, Horiba Y, Yamagami W, Ogawa M, Iwata T, Yanamoto S, Deshimaru R, Banno K, Susumu N, Aoki D.
  • Journal Title: Menopause Review Volume: 14(3) Pages: 161-167
  • DOI: 10.5114/pm.2015.54339
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Osteoporosis is less frequent in endometrial cancer survivors with hypertriglyceridemia. (2015)
  • Author(s): Hirasawa A, Makita K, Akahane T, Yamagami W, Makabe T, Yokota M, Horiba Y, Ogawa M, Yanamoto S, Deshimaru R, Tominaga E, Banno K, Susumu N, Aoki D
  • Journal Title: Jpn J Clin Oncol Volume: 45(1) Issue: 1 Pages: 127-31
  • DOI: 10.1093/jjco/hyu164
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Family history and BRCA1/BRCA2 status among Japanese ovarian cancer (2014)
  • Author(s): Hirasawa A, Masuda K, Akahane T, Kataoka F, Tominaga E, Makita K, Aoki D.
  • Journal Title: Jpn J Clin Oncol 44(1) 49-46 2014 Volume: 44(1) Pages: 46-49
  • Peer Reviewed
• [Journal Article] Polymorphisms of UGT1A1 gene predict adverse effects of irinotecan treatment (2013)
  • Author(s): Hirasawa A, Zama T, Masuda K, Akahane T, Nomura H, Kataoka F, Saito K, Okubo K, Tominaga E, Makita K, Susumu N, Kosaki K, Tanigawara Y, Aoki D.
  • Journal Title: J Hum Genet Volume: 58 Pages: 794-798
  • Peer Reviewed
• [Journal Article] The origin of stroma surrounding epithelial ovarian cancer cells. (2013)
  • Author(s): Akahane T, Hirasawa A, Tsuda H, Kataoka F, Nishimura S, Tanaka H, Tominaga E, Nomura H, Chiyoda T, Iguchi Y, Yamagami W, Susumu N, Aoki D.
  • Journal Title: Int J Gynecol Pathol Volume: 32 Pages: 26-30
  • Peer Reviewed
• [Journal Article] Hypertriglyceridemia is frequent in endometrial cancer survivors. (2013)
  • Author(s): Hirasawa A, Makita K, Akahane T, Yokota M, Yamagami W, Banno K, Susumu N, Aoki D.
  • Journal Title: Jpn J Clin Oncol Volume: 43(11) Issue: 11 Pages: 1087-1092
  • DOI: 10.1093/jjco/hyt125
  • Peer Reviewed
• [Journal Article] Establishment of a system for performing risk-reducing salpingo-oophorectomy (2013)
  • Author(s): Hirasawa A, Masuda K, Akahane T, Tsuruta T, Banno K, Makita K, Susumu N, Jinno H, Kitagawa Y, Sugano K, Kosaki K, Aoki D.
  • Journal Title: Jpn J Clin Oncol Volume: 43 Pages: 515-519
  • Peer Reviewed
• [Journal Article] Distinguishing between lymphangioleiomyomatosis and carcinomatous (2013)
  • Author(s): Hirasawa A, Sato T, Ueno M, Akahane T, Susumu N, Betsuyaku T, Aoki D.
  • Journal Title: J Clin Oncol Volume: 31 Pages: 427-29
  • Peer Reviewed
• [Presentation] 婦人科疾患バイオバンクの現状と家族性腫瘍のスクリーニングに関する検討 (2015)
  • Author(s): 赤羽智子、平沢 晃、増田健太、真壁 健、坂井健良、吉浜智子、山上 亘、野村弘行、片岡史夫、阪埜浩司、進 伸幸、青木大輔
  • Organizer: 第1回 日本産科婦人科遺伝子診療学会
  • Place of Presentation: 長崎ブリックホール（長崎県長崎市）
  • Year and Date: 2015-12-18
• [Presentation] 慶應義塾大学医学部産婦人科におけるバイオバンク (2015)
  • Author(s): 赤羽智子、平沢 晃、増田健太、野田朋美、西尾 浩、仲村 勝、山上 亘、森定 徹、野村弘行、片岡史夫、岩田 卓、田中京子、冨永英一郎、鈴木 淳、阪埜浩司、牧田和也、進 伸幸、青木大輔
  • Organizer: 第60回 日本人類遺伝学会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2015-10-14
• [Presentation] 細胞診標本中に出現する微量細胞からの遺伝子解析 (2015)
  • Author(s): 赤羽智子、平沢 晃、冨永英一郎、青木大輔
  • Organizer: 第56回 日本臨床細胞学会総会（春期大会）
  • Place of Presentation: 松江テルサおよびくにびきメッセ（島根県松江市）
  • Year and Date: 2015-06-12
• [Presentation] BRCA1/2遺伝子生殖細胞変異例における良性卵管上皮細胞のp53蛋白発現とTP53遺伝子変異の意義 (2015)
  • Author(s): 赤羽智子、平沢 晃、増田健太、片岡史夫、冨永英一郎、阪埜浩司、進 伸幸、田中 守、青木大輔
  • Organizer: 第67回 日本産科婦人科学会学術講演会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-04-10
• [Presentation] 細胞診検体からの遺伝子診断を志向した微量細胞からの遺伝子解析の試み (2013)
  • Author(s): 赤羽智子、冨永英一郎、山上 亘、野村 弘行、片岡 史夫、平沢 晃、進 伸幸、青木大輔
  • Organizer: 第54回日本臨床細胞学会総会（春期大会)
  • Place of Presentation: 東京
• [Presentation] TP53 status of fallopian tubes in BRCA1 or BRCA2 mutant patients (2013)
  • Author(s): Tomoko Akahane, Akira Hirasawa, Kenta Masuda, Tomohiko Tsuruta, Hiroyuki Nomura, Fumio Kataoka, Eiichiro Tominaga, Kouji Banno, Nobuyuki Susumu, Kaori Kameyama Daisuke Aoki
  • Organizer: 第72回日本癌学会抄録
  • Place of Presentation: 横浜
• [Presentation] BRCA1/2遺伝子変異保持者における卵管上皮細胞のp53 statusとその意義 (2013)
  • Author(s): 赤羽 智子、冨永 英一郎、平沢 晃、片岡 史夫、増田 健太、植木 有紗、阪埜 浩司、進 伸幸、亀山 香織、青木 大輔
  • Organizer: 第52回日本臨床細胞学会秋期大会
  • Place of Presentation: 大阪
• [Presentation] 日本人卵巣癌における血縁腫瘍歴の頻度およびBRCA1/2遺伝子変異保持者卵管細胞のp53変異に関する検討 (2013)
  • Author(s): 赤羽 智子、平沢 晃、増田 健太、冨永 英一郎、片岡 史夫、野村 弘行、鶴田 智彦、植木 有紗、阪埜 浩司、進 伸幸、菅野 康吉、小崎 健次郎、亀山 香織、青木 大輔
  • Organizer: 第58回日本人類遺伝学会抄録（仙台 2013）
  • Place of Presentation: 仙台