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Alteration of tumor immunity and anti-cancer drug / hormone sensitivity in endometrial cancer with frequent MMR mechanism abnormality

Research Project

Project/Area Number 25462612
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKeio University

Principal Investigator

SUSUMU NOBUYUKI  慶應義塾大学, 医学部, 准教授 (90206459)

Research Collaborator YAMAGAMI Wataru  
NODA Tomomi  
SAKAI Kensuke  
MAKABE Takesi  
NINOMIYA Tomomi  
HIRASAWA Akira  
KATAOKA Fumio  
NOMURA Hiroyuki  
BANNO Kouji  
AOKI Daisuke  
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords子宮内膜癌 / 腫瘍免疫 / 黄体ホルモン療法 / 化学療法 / MMR / ホルモン感受性
Outline of Final Research Achievements

The MSI-positive tumors showed significantly higher grades and larger numbers of TILs than MSI-negative tumors. The COX-2-high group showed fewer TILs than COX-2-low group. Multivariate analysis identified a low number of TILs, positive lymph node involvement, and high tumor malignancy grade as factors independently associated with poor prognosis. The number of TILs, which was increased by MSI and decreased by COX-2 expression, was associated with a poorer prognosis in patients with endometrial cancer. We also propose that COX-2 may block MSI-activated TILs in the tumor microenvironment. Regarding fertility-preserving hormonal therapy, we performed hormonal therapy for 214 young patients with atypical endometrial hyperplasia or endometrioid adenocarcinoma G1. We succeeded in 83 pregnancies in 62 patients and showed 7.5% as the frequency of double cancer, and also revealed the safety and effectiveness of repeated MPA therapy after recurrence with the low incidence of double cancer.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (64 results)

All 2016 2015 2014 2013

All Journal Article (25 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 18 results,  Open Access: 9 results,  Acknowledgement Compliant: 3 results) Presentation (33 results) (of which Int'l Joint Research: 5 results,  Invited: 5 results) Book (6 results)

  • [Journal Article] Retrospective Analysis on the Feasibility and Efficacy of Docetaxel-Cisplatin Therapy for Recurrent Endometrial Cancer.2016

    • Author(s)
      Ninomiya T, Yamagami W, Susumu N, Makabe T, Sakai K, Wada M, Takigawa A, Chiyoda T, Nomura H, Kataoka F, Hirasawa A, Banno K, Aoki D.
    • Journal Title

      Anticancer Res.

      Volume: 36 Pages: 1751-1758

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic factors in patients with uterine carcinosarcoma: a multi-institutional retrospective study from the Japanese Gynecologic Oncology Group.2016

    • Author(s)
      Harano K, Hirakawa A, Yunokawa M, Nakamura T, Satoh T, Nishikawa T, Aoki D, Ito K, Ito K, Nakanishi T, Susumu N, Takehara K, Watanabe Y, Watari H, Saito T.
    • Journal Title

      Int J Clin Oncol.

      Volume: 21 Issue: 1 Pages: 168-176

    • DOI

      10.1007/s10147-015-0859-7

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Optimal cytoreductive surgery in patients with advanced uterine carcinosarcoma: A multi-institutional retrospective study from the Japanese gynecologic oncology group.2016

    • Author(s)
      Harano K, Hirakawa A, Yunokawa M, Nakamura T, Satoh T, Nishikawa T, Aoki D, Ito K, Ito K, Nakanishi T, Susumu N, Takehara K, Watanabe Y, Watari H, Saito T
    • Journal Title

      Gynecol Oncol.

      Volume: 22

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The importance of para-aortic lymph nodes in sentinel lymph node mapping for endometrial cancer by using hysteroscopic radio-isotope tracer injection combined with subserosal dye injection: Prospective study.2016

    • Author(s)
      Kataoka F, Susumu N, Yamagami W, Kuwahata M, Takigawa A, Nomura H, Takeuchi H, Nakahara T, Kameyama K, Aoki D.
    • Journal Title

      Gynecol Oncol.

      Volume: 140 Issue: 3 Pages: 400-404

    • DOI

      10.1016/j.ygyno.2015.12.023

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Factors affecting pregnancy outcomes in young women treated with fertility-preserving therapy for well-differentiated endometrial cancer or atypical endometrial hyperplasia.2016

    • Author(s)
      Inoue O, Hamatani T, Susumu N, Yamagami W, Ogawa S, Takemoto T, Hirasawa A, Banno K, Kuji N, Tanaka M, Aoki D.
    • Journal Title

      Reprod Biol Endocrinol

      Volume: 14(1) Issue: 1 Pages: 2-2

    • DOI

      10.1186/s12958-015-0136-7

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intravenous low-grade endometrial stromal sarcoma with intracardiac extension: A CASE OF inaccurate tumor location on contrast-enhanced computed tomography.2016

    • Author(s)
      Nogami Y, Yamagami W, Maki J, Banno K, Susumu N, Tomita K, Matsubara K, Obara H, Kitagawa Y, Aoki D.
    • Journal Title

      Mol Clin Oncol.

      Volume: 4 Pages: 179-182

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anisakiasis mimics cancer recurrence: two cases of extragastrointestinal anisakiasis suspected to be recurrence of gynecological cancer on PET-CT and molecular biological investigation.2016

    • Author(s)
      Nogami Y, Fujii-Nishimura Y, Banno K, Suzuki A, Susumu N, Hibi T, Murakami K, Yamada T, Sugiyama H, Morishima Y, Aoki D.
    • Journal Title

      BMC Med Imaging.

      Volume: 16 Issue: 1 Pages: 31-41

    • DOI

      10.1186/s12880-016-0134-z

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 【産婦人科処方実践マニュアル】 子宮内膜増殖症(異型増殖症を含む)2016

    • Author(s)
      進 伸幸, 青木大輔
    • Journal Title

      産科と婦人科

      Volume: 83 Pages: 128-130

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Clinicopathologic analysis with immunohistochemistry for DNA mismatch repair protein expression in synchronous primary endometrial and ovarian cancers.2015

    • Author(s)
      Kobayashi Y, Nakamura K, Nomura H, Banno K, Irie H, Adachi M, Iida M, Umene K, Nogami Y, Masuda K, Kisu I, Ueki A, Yamagami W, Kataoka F, Hirasawa A, Tominaga E, Susumu N, Aoki D.
    • Journal Title

      International Journal of Gynecological Cancer

      Volume: 25(3) Issue: 3 Pages: 440-446

    • DOI

      10.1097/igc.0000000000000377

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Osteoporosis is less frequent in endometrial cancer survivors with hypertriglyceridemia.2015

    • Author(s)
      Hirasawa A, Makita K, Akahane T, Yamagami W, Makabe T, Yokota M, Horiba Y, Ogawa M, Yanamoto S, Deshimaru R, Tominaga E, Banno K, Susumu N, Aoki D
    • Journal Title

      Jpn J Clin Oncol

      Volume: 45(1) Issue: 1 Pages: 127-31

    • DOI

      10.1093/jjco/hyu164

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] How do Japanese gynecologists view hormone replacement therapy for survivors of endometrial cancer? Japanese Gynecologic Oncology Group (JGOG) survey.2015

    • Author(s)
      Yokoyama Y, Ito K, Takamatsu K, Takehara K, Nakanishi T, Harano K, Watari H, Susumu N, Aoki D, Saito T.
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 20 Issue: 5 Pages: 997-1004

    • DOI

      10.1007/s10147-015-0808-5

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Intratumoral CD8+ Lymphocyte Infiltration as a Prognostic Factor and Its Relationship With Cyclooxygenase 2 Expression and Microsatellite Instability in Endometrial Cancer.2015

    • Author(s)
      Suemori T, Susumu N, Iwata T, Banno K, Yamagami W, Hirasawa A, Sugano K, Matsumoto E, Aoki D.
    • Journal Title

      Int J Gynecol Cancer

      Volume: 25(7) Issue: 7 Pages: 1165-1172

    • DOI

      10.1097/igc.0000000000000482

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathological factors associated with omental metastases in endometrial cancer.2015

    • Author(s)
      Sakai K, Yamagami W, Susumu N, Nomura H, Kataoka F, Banno K, Tsuda H, Aoki D.
    • Journal Title

      Eur J Gynaecol Oncol.

      Volume: 36 Pages: 397-401

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effectiveness of third-line chemotherapy in recurrent ovarian cancer patients.2015

    • Author(s)
      Yoshihama T, Chiyoda T, Kataoka F, Nomura H, Iguchi Y, Hashimoto S, Yamagami W, Tominaga E, Susumu N, Tsuda H, Aoki D.
    • Journal Title

      Eur J Gynaecol Oncol.

      Volume: 36 Pages: 424-427

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hysteroscopic transcervical resection is useful to diagnose myometrial invasion in atypical polypoid adenomyoma coexisting with atypical endometrial hyperplasia or endometrial cancer with suspicious myometrial invasion.2015

    • Author(s)
      Yamagami W, Susumu N, Ninomiya T, Nakadaira N, Iwasa N, Kuwahata M, Nomura H, Kataoka F, Banno K, Aoki D.
    • Journal Title

      J Obstet Gynaecol Res.

      Volume: 41 Issue: 5 Pages: 768-775

    • DOI

      10.1111/jog.12645

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polymorphisms of estrogen metabolism-related genes ESR1, UGT2B17, and UGT1A1 are not associated with osteoporosis in artificial menopausal Japanese women.2015

    • Author(s)
      Yokota M, Hirasawa A, Makita K, Akahane T, Sakai K, Makabe T, Horiba Y, Yamagami W, Ogawa M, Iwata T, Yanamoto S, Deshimaru R, Banno K, Susumu N, Aoki D.
    • Journal Title

      Menopause Review

      Volume: 14(3) Pages: 161-167

    • DOI

      10.5114/pm.2015.54339

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 解剖に基づいた腹腔鏡手術のトレーニング2015

    • Author(s)
      片岡史夫, 中平直希, 二宮委美, 今西宣晶, 進 伸幸, 平形道人, 相磯貞和, 青木大輔
    • Journal Title

      産科と婦人科

      Volume: 82 Pages: 1284-1289

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 【女性ヘルスケア集中講義!-次世代の女性医学の可能性を求めて-】 外来でできる婦人科がんの予防とヘルスケア指導 子宮体がんの予防とヘルスケア2015

    • Author(s)
      進 伸幸, 平沢 晃, 山上 亘, 青木大輔
    • Journal Title

      産婦人科の実際

      Volume: 64 Pages: 1741-1750

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 【子宮内膜癌治療の最前線】 子宮内膜癌治療における臨床試験の現況 抗がん剤を中心に2015

    • Author(s)
      進 伸幸, 野村弘行, 山上 亘, 片岡 史夫, 青木大輔
    • Journal Title

      産婦人科の実際

      Volume: 64 Pages: 669-677

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 【子宮内膜癌治療の最前線】 子宮内膜癌に対する術後補助療法2015

    • Author(s)
      寒河江悟, 進 伸幸
    • Journal Title

      産婦人科の実際

      Volume: 64 Pages: 643-649

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Current status of molecular-targeted drugs for endometrial cancer (Review).2014

    • Author(s)
      Nogami Y, Banno K, Kisu I, Yanokura M, Umene K, Masuda K, Kobayashi Y, Yamagami W, Nomura H, Tominaga E, Susumu N, Aoki D
    • Journal Title

      Mol Clin Oncol.

      Volume: 1 Pages: 799-804

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Candidate biomarkers for genetic and clinicopathological diagnosis of endometrial cancer.2013

    • Author(s)
      Banno K, Nogami Y, Kisu I, Yanokura M, Umene K, Masuda K, Kobayashi Y, Yamagami W, Susumu N, Aoki D.
    • Journal Title

      Int J Mol Sci.

      Volume: 14 Issue: 6 Pages: 12123-12137

    • DOI

      10.3390/ijms140612123

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] New candidate therapeutic agents for endometrial cancer: potential for clinical practice (review).2013

    • Author(s)
      Umene K
    • Journal Title

      Oncol Rep

      Volume: 29 Issue: 3 Pages: 855-860

    • DOI

      10.3892/or.2013.2221

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 国内外の子宮体がんの臨床試験の現状2013

    • Author(s)
      進 伸幸、野村弘行、山上 亘、片岡史夫、阪埜浩司、寒河江悟、青木大輔
    • Journal Title

      産婦人科の実際

      Volume: 62 Pages: 1828-1842

    • Related Report
      2013 Research-status Report
  • [Journal Article] 子宮体がんとエストロゲン2013

    • Author(s)
      進 伸幸、山上 亘、二宮委美、桑波田美智子、片岡史夫、平沢 晃、阪埜浩司、青木大輔
    • Journal Title

      産婦人科の実際

      Volume: 62 Pages: 1181-1187

    • Related Report
      2013 Research-status Report
  • [Presentation] 子宮体癌に対する腹腔鏡手術の適応という観点から見た術前診断の精度2016

    • Author(s)
      進 伸幸 山上 亘 野村 弘行 片岡 史夫 青木 大輔
    • Organizer
      第2回悪性腫瘍内視鏡手術セミナー
    • Place of Presentation
      ホテルサンルートプラザ名古屋(愛知県名古屋市)
    • Year and Date
      2016-03-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] オープンディスカッション 子宮体癌委員会子宮体癌術後再発Low-intermediate risk(LIR)症例における術後化学療法の効果に関する前方視的無作為比較試験案2015

    • Author(s)
      進 伸幸
    • Organizer
      第14回 JGOG総会
    • Place of Presentation
      コクヨホール(東京都港区)
    • Year and Date
      2015-12-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 子宮体癌早期病変・前駆病変の臨床における病理診断・細胞診断の重要性2015

    • Author(s)
      進 伸幸, 山上 亘, 平沢 晃, 片岡史夫, 青木大輔
    • Organizer
      第43回 日本婦人科病理学会
    • Place of Presentation
      東京女子医大(東京都新宿区)
    • Year and Date
      2015-12-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] 子宮体部漿液性腺癌の早期診断に子宮内膜細胞診が有用であった2例の検討2015

    • Author(s)
      坂井健良, 進 伸幸, 山上 亘, 真壁 健, 二宮委美, 南木佳子, 岩佐尚美, 中平直希, 野村弘行, 片岡史夫, 平沢 晃, 田中京子, 阪埜浩司, 青木大輔
    • Organizer
      第54回 日本臨床細胞学会秋季大会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 若年子宮体癌, および子宮内膜異型増殖症に対する妊孕性温存治療による精神的影響2015

    • Author(s)
      横田めぐみ, 山上 亘, 牧田和也, 進 伸幸, 青木大輔
    • Organizer
      第31回 日本女性医学学会
    • Place of Presentation
      メルパルク名古屋(愛知県名古屋市)
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 本格的な施行開始後3年目を迎えた子宮体癌術後患者の卵巣欠落症状に対するエストロゲン療法(ET)の現状2015

    • Author(s)
      牧田和也, 横田めぐみ, 堀場裕子, 山上 亘, 平沢 晃, 小川真里子, 弟子丸亮太, 柳本茂久, 阪埜浩司, 進 伸幸, 高松 潔, 青木大輔
    • Organizer
      第30回 日本女性医学学会
    • Place of Presentation
      メルパルク名古屋(愛知県名古屋市)
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 40歳以上の子宮体癌に対する高用量MPA療法は有用か2015

    • Author(s)
      山上 亘, 進 伸幸, 真壁 健, 二宮委美, 和田美智子, 野村弘行, 片岡史夫, 平沢 晃, 阪埜浩司, 青木大輔
    • Organizer
      第53回 日本癌治療学会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2015-10-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] G-CSF適正使用ガイドライン一部改訂にかかるコンセンサスミーティング 「対象患者」「放射線併用時」「FN発症頻度(婦人科がん)」における一部改訂について2015

    • Author(s)
      進 伸幸, 西尾 浩
    • Organizer
      第53回日本癌治療学会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2015-10-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Investigation of double cancer arising in young patients with endometrial cancer who receive fertility-preserving hormonal therapy using medroxyprogesterone acetate.2015

    • Author(s)
      Susumu N, Yamagami W, Sakai K, Makabe T, Ninomiya T, Wada M, Ichikawa Y, Nomura H, Hirasaawa A, Kataoka F, Hirasawa A, Tominaga E, Suzuki A, Banno K, Aoki D.
    • Organizer
      19th International Meeting of The European Society of Gynaecological Oncology (ESGO).
    • Place of Presentation
      ニース(フランス)
    • Year and Date
      2015-10-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The relationship between the RI account of sentinel lymph nodes and lymph node metastasis in endometrial cancer.2015

    • Author(s)
      Sakai K, Yamagami W, Susumu N, Makabe T, Ninomiya T, Nakadaira N, Iwasa N, Wada M, Nomura H, Kataoka F, Tanaka K, Banno K, Aoki D.
    • Organizer
      19th International Meeting of The European Society of Gynaecological Oncology (ESGO)
    • Place of Presentation
      ニース(フランス)
    • Year and Date
      2015-10-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of pre- or intra-operative diagnostic method for uterine carcinosarcoma.2015

    • Author(s)
      Makabe T, Yamagami W, Susumu N, Sakai K, Yoshihama T, Iwasa N, Nakadaira N, Ninomiya T, Wada M, Takigawa A, Nomura H, Kataoka F, Hirasawa A, Banno K, Aoki D.
    • Organizer
      19th International Meeting of The European Society of Gynaecological Oncology (ESGO)
    • Place of Presentation
      ニース(フランス)
    • Year and Date
      2015-10-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ⅰ期、Ⅱ期の子宮体部類内膜腺がんにおける再発リスク因子の検討2015

    • Author(s)
      小塙理人, 山上 亘, 二宮委美, 坂井健良, 真壁 健, 野村弘行, 片岡史夫, 平沢 晃, 阪埜浩司, 進 伸幸, 田中 守, 青木大輔
    • Organizer
      第130回 関東連合産科婦人科学会
    • Place of Presentation
      幕張メッセ国際会議場(千葉県千葉市)
    • Year and Date
      2015-10-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 慶應義塾大学医学部産婦人科におけるバイオバンク2015

    • Author(s)
      赤羽智子, 平沢 晃, 増田健太, 野田朋美, 西尾 浩, 仲村 勝, 山上 亘, 森定 徹, 野村弘行, 片岡史夫, 岩田 卓, 田中京子, 冨永英一郎, 鈴木 淳, 阪埜浩司, 牧田和也, 進 伸幸, 青木大輔
    • Organizer
      第60回 日本人類遺伝学会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2015-10-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] Usefulness of intra-operative touch imprinting cytology of sentinel lymph nodes in endometrial cancer for improving intra-operative diagnostic accuracy.2015

    • Author(s)
      Susumu N, Yamagami W, Kataoka F, Makabe T, Sakai K, Ninomiya T, Takigawa A, Nomura H, Hirasaawa A, Banno K, Nakahara T, Kameyama K, Aoki D.
    • Organizer
      39th European Congress of Cytology.
    • Place of Presentation
      ミラノ(イタリア)
    • Year and Date
      2015-09-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 画像診断で深い筋層浸潤が否定できない若年体癌患者に対して経頸管的腫瘍切除による病理検索が妊孕性の温存の可否の判断に有用であった1例2015

    • Author(s)
      進 伸幸, 山上 亘, 真壁 健, 坂井健良, 二宮委美, 野村弘行, 片岡史夫, 阪埜浩司, 青木大輔
    • Organizer
      第55回 日本産科婦人科内視鏡学会学術講演会
    • Place of Presentation
      神パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 当院における子宮体癌術後再発低リスク群における再発症例の検討2015

    • Author(s)
      坂井健良, 山上 亘, 進 伸幸, 真壁 健, 二宮委美, 岩佐尚美, 中平直希, 野村弘行, 片岡史夫, 平沢 晃, 冨永英一郎, 阪埜浩司, 青木大輔
    • Organizer
      第57回 日本婦人科腫瘍学会
    • Place of Presentation
      アイーナいわて県民情報交流センター・マリオス盛岡地域交流センター(岩手県盛岡市)
    • Year and Date
      2015-08-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 子宮癌肉腫症例における子宮内膜細胞診の検討2015

    • Author(s)
      真壁 健, 山上 亘, 坂井健良, 二宮委美, 和田美智子, 野村弘行, 片岡史夫, 阪埜浩まる司, 進 伸幸, 青木大輔
    • Organizer
      第56回日本臨床細胞学会総会(春期大会)
    • Place of Presentation
      くにびきメッセ・松江テレサ(島根県松江市)
    • Year and Date
      2015-06-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] Clinicopathological features of endometrial cancer after tamoxifen as postoperative adjuvant therapy for breast cancer.2015

    • Author(s)
      Adachi M, Banno K, Yanokura M, Irie H, Iida M, Nakamura K, Umene K, Nogami Y, Masuda K, Ueki A, Kisu I, Yamagami W, Tominaga E, Susumu N, Aoki D
    • Organizer
      24th Asian & Oceanic Congress of Obstetrics & Gynaecology (AOCOG 2015)
    • Place of Presentation
      サラワク(マレーシア)
    • Year and Date
      2015-06-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 子宮体癌の予防・診断・妊孕性温存2015

    • Author(s)
      進 伸幸
    • Organizer
      第525回 横浜市産婦人科医会平成27年6月例回研究会
    • Place of Presentation
      横浜市健康福祉総合センター(神奈川県横浜市)
    • Year and Date
      2015-05-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 子宮体癌診療のupdate -予防、診断、手術、化学療法、妊孕性温存療法-2015

    • Author(s)
      進 伸幸
    • Organizer
      道南産科婦人科医会学術講演会
    • Place of Presentation
      ベルクラシック(北海道函館市)
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Is repeated fertility-preserving hormonal therapy using medroxyprogesterone acetate acceplable for young patients with recurrent endomatrisl cancer or atypical hyperplasia?2015

    • Author(s)
      Sakai K, Susumu N, Makabe T, Ninomiya T, Yamagami W, Ichikawa Y, Nomura H, Kataoka F, Hirasawa A, Banno K, Tanaka M, Aoki D
    • Organizer
      第67回 日本産科婦人科学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-04-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] A retrospective analysis of docetaxel-cisplatin chemotherapy (DP chemotherapy) for recurrent endometrial cancer2013

    • Author(s)
      Wataru Yamagami, Nobuyuki Susumu, Tomomi Ninomiya, Michiko Kuwahata, Aya Takigawa, Hiroyuki Nomura, Fumio Kataoka, Eiichiro Tominaga, Kouji Banno, Daisuke Aoki
    • Organizer
      18th International Meeting of the European Society of Gynaecological Oncology (ESGO)
    • Place of Presentation
      Liverpool, UK
    • Related Report
      2013 Research-status Report
  • [Presentation] Usefulness of transcervical tumor resection in diagnosing myometrial invasion for young patients with endometrial cancer who received fertility-preserving progesterone therapy2013

    • Author(s)
      Nobuyuki Susumu, Wataru Yamagami, Tomomi Ninomiya, Michiko Kuwahata, Aya Takigawa, Hiroyuki Nomura, Fumio Kataoka, Eiichiro Tominaga, Atsushi Suzuki, Koji Banno, Daisuke Aoki
    • Organizer
      3rd Biennial Meeting of Asian Society of Gynecologic Oncology (ASGO)
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] 子宮体癌における妊孕性温存黄体ホルモン療法後の再発予後因子の検討2013

    • Author(s)
      進 伸幸、山上 亘、市川義一、野村弘行、片岡史夫、平沢 晃、冨永英一郎、鈴木 淳、阪埜浩司、塚崎克己、青木大輔
    • Organizer
      第54回日本臨床細胞学会総会(春期大会)
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 婦人科腫瘍のoncofertility2013

    • Author(s)
      浜谷敏雄、進 伸幸、藤井多久磨、久慈直昭、吉村泰典、青木大輔
    • Organizer
      第54回日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 若年子宮体癌に対する妊孕性温存療法後の子宮内再発診断における子宮内膜細胞診の2013

    • Author(s)
      山上 亘、進 伸幸、桑波田美智子、滝川 彩、横田めぐみ、野村弘行、片岡史夫、
    • Organizer
      第54回日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 画像診断で筋層浸潤が否定できない高用量黄体ホルモン療法施行後の若年体癌症例に対して、経頚管的腫瘍切除による筋層浸潤判定は有用か?2013

    • Author(s)
      進 伸幸 山上 亘 二宮 委美 桑波田 美智子 滝川 彩 横田めぐみ 野村 弘行 片岡 史夫 阪埜 浩司 青木 大輔 吉村泰典
    • Organizer
      第53回日本産科婦人科内視鏡学会学術講演会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
  • [Presentation] 子宮鏡下手術にて筋層浸潤が否定され、高用量MPA療法後に妊娠分娩に至った類内膜腺癌G1共存異型ポリープ状腺筋腫の3例2013

    • Author(s)
      山上 亘 進 伸幸 二宮 委美 桑波田 美智子 滝川 彩 野村 弘行 片岡 史夫 冨永英一郎、阪埜 浩司 青木 大輔
    • Organizer
      第53回日本産科婦人科内視鏡学会学術講演会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
  • [Presentation] クリニカルカンファレンス7(腫瘍):婦人科腫瘍に対する縮小・機能温存治療2013

    • Author(s)
      進 伸幸
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 若年体癌症例に対する高用量黄体ホルモン(MPA)療法後の生児獲得率2013

    • Author(s)
      滝川 彩 山上 亘 進 伸幸 市川義一  横田めぐみ 片岡史夫
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] 高用量黄体ホルモン療法後に妊娠に至った若年性子宮体癌および複雑型子宮内膜異型増殖症43例の妊娠予後と分娩後のサーベイランス2013

    • Author(s)
      山上 亘 進 伸幸 市川 義一 桑波田 美智子 野村 弘行 平沢 晃 峰岸一宏 冨永 英一郎 宮越 敬 阪埜 浩司 青木 大輔 吉村 泰典
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] JGOG2043後の子宮体癌に対する第III相大規模試験の方向性の検討2013

    • Author(s)
      進 伸幸
    • Organizer
      第12回JGOG年次総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 再発子宮体癌に対するDP(ドセタキセル+シスプラチン)療法21例の検討2013

    • Author(s)
      二宮 委美、山上 亘、進 伸幸、桑波田 美智子、滝川 彩、野村 弘行、片岡 史夫
    • Organizer
      第51回日本癌治療学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Book] 産科婦人科疾患 最新の治療 2016-20182016

    • Author(s)
      編集: 吉川史隆、倉智博久、平松祐司   分担著者:進 伸幸
    • Total Pages
      356
    • Publisher
      南江堂
    • Related Report
      2015 Annual Research Report
  • [Book] 患者さんとご家族のための 子宮頸がん 子宮体がん 卵巣がん 治療ガイドライン2016

    • Author(s)
      編集:日本婦人科腫瘍学会   分担著者:進 伸幸
    • Total Pages
      250
    • Publisher
      金原出版
    • Related Report
      2015 Annual Research Report
  • [Book] NHKテレビテキスト きょうの健康2015

    • Author(s)
      分担著者:進 伸幸
    • Total Pages
      146
    • Publisher
      NHK出版
    • Related Report
      2015 Annual Research Report
  • [Book] G-CSF適正使用ガイドライン 2013年版 Ver.22015

    • Author(s)
      一般社団法人 日本癌治療学会
    • Total Pages
      92
    • Publisher
      金原出版
    • Related Report
      2015 Annual Research Report
  • [Book] 婦人科癌診療Q&A 一つ上を行く診療の実践2014

    • Author(s)
      進 伸幸、山上 亘、青木大輔
    • Total Pages
      339
    • Publisher
      中外医学社
    • Related Report
      2013 Research-status Report
  • [Book] 新 癌についての質問に答える 第2版2013

    • Author(s)
      進 伸幸
    • Total Pages
      531
    • Publisher
      へるす出版
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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