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Analysis of molecular mechanism of lymphatic metastasis of gynecologic malignant tumor

Research Project

Project/Area Number 25462613
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKeio University

Principal Investigator

MORISADA TOHRU  慶應義塾大学, 医学部, 助教 (70317923)

Co-Investigator(Kenkyū-buntansha) FUJINO Akihiro  慶應義塾大学, 医学部, 講師 (50306726)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsリンパ管内皮細胞 / 婦人科悪性腫瘍 / リンパ管腫
Outline of Final Research Achievements

We have been analyzing molecular interaction between tumor cells and lymphatic endothelium using lymphatic endothelial cell (LEC) line and gynecologic cancer cell line. After establishment of immortalization and cultivation of LEC, we observed elevated expression of cell adhesion molecules on LEC by adding inflammatory cytokine, TNFα. The lymphatic vessels are supposed to have a certain role in lymphatic metastasis by promoting cell adhesion. It was confirmed that a uterine cervical cancer cell, SKG-2 formed cell spheroid in a three-dimensional culture dish. It is suggested that this cell spheroid possesses the biological character mimicking the gynecologic tumor in cancer microenvironment.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (1 results)

All 2015

All Journal Article (1 results)

  • [Journal Article] 悪性腫瘍におけるリンパ管新生2015

    • Author(s)
      森定徹、青木大輔
    • Journal Title

      産科と婦人科

      Volume: 82(2) Pages: 147-153

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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