| Project/Area Number |
25462616
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Dokkyo Medical University (2015)
Jikei University School of Medicine (2013) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YANAIHARA Nozomu 東京慈恵会医科大学, 医学部, 講師 (20349624)
YAMADA Kyosuke 東京慈恵会医科大学, 医学部, 准教授 (30230452)
落合 和徳 東京慈恵会医科大学, 医学部, 教授 (20152514)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 卵巣癌 / 明細胞腺癌 / バイオマーカー / IL-6 / IL-&R / 卵巣明細胞腺癌 |
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| Outline of Final Research Achievements |
The multivariate analysis indicated that non-optimal staging surgery predicted worse recurrence-free survival (RFS) than the optimal staging surgery in stages IA/IC1 ovarian clear cell adenocarcinoma (CCC) patients by a retrospective review of 165 stage I CCC patients. The multivariate analysis indicated that advanced stages, hyperhemoglobinemia, thrombocytosis, higher creatinine level, and higher C-reactive protein level predicted worse PFS by a retrospective review of 98 CCC patinets.
A total of 84 CCC cases collected from primary surgical specimens were evaluated by the immunohistochemical analysis for IL-6R and phosphorylated Stat3, and we found that high IL-6R expression correlated with poor patient survival by the multivariate analyses, suggesting that IL-6/IL-6R signaling pathway could be implicated in the progression of CCC.
Inhibition of endogenous IL-6R including tocilizumab in CCC cells did reduce cell invasion ability and restored their response to cytotoxic reagent.
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