Search for the biomarkers for the survival of patients of ovariacn clear cell adenocarcinoma
Project/Area Number |
25462616
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Obstetrics and gynecology
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Research Institution | Dokkyo Medical University (2015) Jikei University School of Medicine (2013) |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
YANAIHARA Nozomu 東京慈恵会医科大学, 医学部, 講師 (20349624)
YAMADA Kyosuke 東京慈恵会医科大学, 医学部, 准教授 (30230452)
落合 和徳 東京慈恵会医科大学, 医学部, 教授 (20152514)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 卵巣癌 / 明細胞腺癌 / バイオマーカー / IL-6 / IL-&R / 卵巣明細胞腺癌 |
Outline of Final Research Achievements |
The multivariate analysis indicated that non-optimal staging surgery predicted worse recurrence-free survival (RFS) than the optimal staging surgery in stages IA/IC1 ovarian clear cell adenocarcinoma (CCC) patients by a retrospective review of 165 stage I CCC patients. The multivariate analysis indicated that advanced stages, hyperhemoglobinemia, thrombocytosis, higher creatinine level, and higher C-reactive protein level predicted worse PFS by a retrospective review of 98 CCC patinets. A total of 84 CCC cases collected from primary surgical specimens were evaluated by the immunohistochemical analysis for IL-6R and phosphorylated Stat3, and we found that high IL-6R expression correlated with poor patient survival by the multivariate analyses, suggesting that IL-6/IL-6R signaling pathway could be implicated in the progression of CCC. Inhibition of endogenous IL-6R including tocilizumab in CCC cells did reduce cell invasion ability and restored their response to cytotoxic reagent.
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Report
(3 results)
Research Products
(6 results)
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[Presentation] staging laparotomyでFIGOI期とした卵巣癌の術後化学療法の意義.2015
Author(s)
鈴木 佳世, 斉藤 元章, 川畑 絢子, 鈴木 二郎, 飯田 泰志, 上田 和, 矢内原 臨, 田部 宏, 高野 浩邦, 山田 恭輔, 礒西 成治, 落合 和彦, 佐々木 寛, 高倉 聡, 岡本 愛光.
Organizer
第57回日本婦人科腫瘍学会
Place of Presentation
アイーナいわて県民情報交流センター(岩手県盛岡市)
Year and Date
2015-08-07
Related Report
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