| Project/Area Number |
25462617
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Toho University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 原発性腹膜癌 / 網羅的解析 / マイクロアレイ / 遺伝子発現 / 予後因子 / 臨床病理学的解析 / 術前化学療法 / 腫瘍減量術 / 腹膜癌 / バイオマーカー / 分子標的 / ribosomal protein / chemokine / cytokine |
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| Outline of Final Research Achievements |
We identified the gene clusters, RPL9, RPL10, RPL12, RPL19, RPL27A, RPL31, RPS3, RPS4X, RPS15A, RPS18, CCL5, which are suggested to be involved with the pathogenesis of primary peritoneal cancer by comprehensive gene analysis. These genes are likely to be available for the molecular diagnosis and molecular target therapy of primary peritoneal cancer. Futhermore, We identified sevaral important prognostic factors of patients with primary peritoneal cancer. Neoadjuvant chemotherapy with interval debulking surgery is a reasonable treatment strategy and complete debulking surgery is optimum.
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