Investigation of cell characteristics of cancer metastasis and drug resistance using gynecological cancer's specific sugar chains.
| Project/Area Number |
25462623
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Sasaki Foundation |
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Principal Investigator |
SAKAMOTO Masaru 公益財団法人佐々木研究所, その他部局等, 研究員 (20260101)
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| Co-Investigator(Renkei-kenkyūsha) |
KIKUCHI Ryoko 公益財団法人佐々木研究所, 附属研究所, 研究員 (80535063)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | レザフィリン / PDT / 子宮頸癌 / ガレクチン-4 / PDT(光線力学的療法) / 子宮頸がん |
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| Outline of Final Research Achievements |
To take a photosensitizer more specifically in cancer at PDT (photodynamic therapy) of gynecological cancer by application of sugar chains and its binding molecules, lectins, we tried to identify the glycoproteins which participate in cancer specific uptake of the photosensitizer, laserphyrin. We compared laserphyrin uptake of the cell lines of cervical cancer with the uptake of immortalized cells from normal cervix uteri or normal fibroblasts, the uptakes were much the same. However, at an organizational level, tumors took laserphyrin more than non-tumor tissues. To identify the glycoproteins that involve in the cancer specific laserphyrin uptake, we have to make an analysis at tissue level. We also performed analysis of galectin-4, the molecule that participates in sugar binding.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Performance of p16INK4a/Ki-67 immunocytochemistry for identifying CIN2+ in atypical squamous cells of undetermined significance and low-grade squamous intraepithelial lesion specimens: a Japanese Gynecologic Oncology Group study.2015
Author(s)
Fujii T, Saito M, Hasegawa T, Iwata T, Kuramoto H, Kubushiro K, Ohmura M, Ochiai K, Arai H, Sakamoto M, Motoyama T, Aoki D
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Journal Title
International journal of clinical oncology
Volume: 20
Issue: 1
Pages: 134-142
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Synergistic effects of cabozantinib to temozolomide and bevacizumab in patients with heavily pretreated relapsed uterine leiomyosarcoma.2015
Author(s)
Sayaka Ikeda, Kazuya Kudoh, Naoki Sasaki, Masashi Takano, Tomoko Goto, Ryoko Kikuchi, Masaru Sakamoto, Tsunekazu Kita, Nobuyuki Susumu, Daisuke Aoki, Hiroko Kouta, Yoshihiro Kikuchi
Organizer
The 51th Annual Meeting of the American Society of Clinical Oncology (ASCO)
Place of Presentation
Chicago, USA
Year and Date
2015-05-29
Related Report
Int'l Joint Research
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