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Oxidative stress and redox regulation - a brand new protein in an inner ear -

Research Project

Project/Area Number 25462626
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionGunma University

Principal Investigator

Katsumasa Takahashi  群馬大学, 医学(系)研究科(研究院), 准教授 (30326839)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsレドックス / 酸化ストレス / イノシトール3リン酸レセプター / 活性酸素 / dROM / BAP / イノシトール3リン酸レセプター / 内耳障害 / 免疫抑制
Outline of Final Research Achievements

Oxidative stress is an imbalance between the production and the elimination of oxidant species. In cancer and infection, white blood cells overproduce reactive oxygen species, causing the oxidative stress. In the present study, we evaluated the oxidative stress in patients with cancer, and compared the relationship between the oxidative stress and the number of white blood cells (WBC). The diacron-reactive oxygen metabolite (dROM), which indicated the concentration of hydroperoxides in serum, was measured as an index of oxidative stress. The biological antioxidant potential (BAP), which indicated the concentration of deoxidized iron ion in serum, was also measured as an index of anti-oxidative status. We compared head and neck carcinoma patients (HNC) who were treated by chemotherapy and otitis media patients (OM) who had surgery. The dROM was significantly high in HNC, although dROM in OM was normal.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (7 results)

All 2016 2014 2013

All Journal Article (6 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] 頭頸部癌における酸化ストレスの評価2016

    • Author(s)
      高橋克昌、高安幸弘、近松一朗
    • Journal Title

      KMJ THE KITAKANTO MEDICAL JOURNAL

      Volume: 66 Pages: 117-121

    • NAID

      130005253710

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Combined small cell carcinoma of the sinonasal tract associated with syndrome of inappropriate secretion of antidiuretic hormone: A case report2014

    • Author(s)
      Kayakabe M, Takahashi K, Okamiya T, Segawa A, Oyama T, Chikamatsu K
    • Journal Title

      Oncology letters

      Volume: 7 Issue: 4 Pages: 1253-1256

    • DOI

      10.3892/ol.2014.1882

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Improvement of tracheal flap method for laryngotracheal separation.2013

    • Author(s)
      Shino M, Yasuoka Y, Murata T, Ninomiya H, Takayasu T, Takahashi K, Chikamatsu K.
    • Journal Title

      Laryngoscope

      Volume: 123 Issue: 2 Pages: 440-445

    • DOI

      10.1002/lary.23632

    • NAID

      130005467165

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of a new method using narrow band imaging for taste assessment.2013

    • Author(s)
      Shimada T, Kamada H, Hoshino R, Okamiya T, Takahashi K, Chikamatsu K.
    • Journal Title

      Laryngoscope

      Volume: 123 Issue: 10 Pages: 2405-2410

    • DOI

      10.1002/lary.24031

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Alteration of cancer stem cell-like phenotype by histone deacetylase inhibitors in squamous cell carcinoma of the head and neck.2013

    • Author(s)
      Chikamatsu K, Ishii H, Murata T, Sakakura K, Shino M, Toyoda M, Takahashi K, Masuyama K.
    • Journal Title

      Cancer Sci.

      Volume: 104 Issue: 11 Pages: 1468-1475

    • DOI

      10.1111/cas.12271

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] ENGの有用性と限界は?2013

    • Author(s)
      高橋克昌
    • Journal Title

      JOHNS

      Volume: 29 Pages: 1865-1868

    • Related Report
      2013 Research-status Report
  • [Presentation] 唾液中ヘルペスウイルスDNA測定によるメニエール病発作期の疲労度測定2013

    • Author(s)
      高橋克昌, 紫野正人, 新國摂, 岡宮智史, 高安幸弘, 近松一朗
    • Organizer
      日本めまい平衡医学会
    • Place of Presentation
      大阪国際交流センター
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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