| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
No method for reconstruction of temporal bone defects after tympanoplasty or mastoidectomy has yet been established. We have previously provided the first description of using recombinant bone morphogenetic protein 2 (rhBMP-2) on the mastoid cortex of temporal bone. Several reports have since reported animal mastoid obliteration. However, the efficacy of rhBMP-2 in the pneumatic space of temporal bone has not been reported.
In this study rhBMP-2 was injected to the animal temporal bone. Bone mineral density was measured using a micro CT device for animals for 12 months after the injection. Significant increase in bone mineral density was measured by CT scan in rhBMP-2 model compared with control, and it was approaching the density of the untreated side. Development of pneumatization is apparent in the center of the bone regeneration site. This study demonstrated that potential utility of rhBMP-2 for bone regeneration that could contribute to clinical use in ontological surgeries.
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