| Project/Area Number |
25462629
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Shinshu University (2015)
Tokyo Medical and Dental University (2013) |
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Principal Investigator |
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| Research Collaborator |
KITAMURA Ken 東京医科歯科大学, 医歯学総合研究科, 教授 (90010470)
NISHIO Ayako 東京医科歯科大学, 医学部附属病院, 医員 (00611576)
HONDA Keiji 東京医科歯科大学, 医学部附属病院, 医員 (90621079)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 老人性難聴 / 内耳 / 蝸牛 / 加齢 / マイクロRNA / 発現解析 / C57BL/6 / miRNA / mRNA / マイクロCT |
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| Outline of Final Research Achievements |
The aim of the present study is to clarify the important regulatory factors for age-related hearing loss. Exhaustive miRNA expression analyses were performed to the cochleae of C57BL/6, an age-related hearing loss mouse model, at the ages of 1 month, 10 months and 16 months. Non-hierarchical cluster analyses detected six clusters, including 32 miRNAs, which could be associated with age-related hearing loss. The expression levels of 12 miRNAs in three cluster (clusters 1, 5 and 6) among the 6 clusters increased from the age of 1 month to the age of 10 months. The expresion levels of the 12 miRNAs were compared between age-related hearing loss mice (C57BL/6) and non age-related hearing loss mice (C3H/He).
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