Development of cochlear model capable of analyzing mutual interaction between active vibration of the basilar membrane and ionic flow in the cochlea
| Project/Area Number |
25462631
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | The University of Electro-Communications |
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Principal Investigator |
KOIKE Takuji 電気通信大学, 情報理工学(系)研究科, 教授 (10282097)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 蝸牛 / 基底板振動 / イオン流動 / 解析モデル / 臨床応用 / 蝸牛モデル / 有毛細胞 / 能動性 / イオン輸送機構 / 人工内耳 / 外有毛細胞 / 耳音響放射 |
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| Outline of Final Research Achievements |
This research intends to clarify the mechanisms of hearing disorders and to develop better methods of treatments, which are difficult to identify through clinical researches and specimens. Numerical cochlear models in which the active motilities of the outer hair cells and ionic flux are considered have been constructed. Simulations were performed using the models, and the vibrations of the lymph liquid and basilar membrane in the cochlea were analyzed. Through the simulations, the transmission mechanisms in the peripheral auditory systems have been clarified. As clinical applications, the mechanisms of hearing losses caused by otosclerosis and endolymphatic hydrops were investigated. In addition, optimal design of cochlear implant was studied, and the effects of the length and insert position of the electrode of the cochlear implant on residual hearing were investigated.
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Report
(3 results)
Research Products
(11 results)
