Diagnosis of endolymphatic hydrops using 3T MRI in patients with Meniere's disease.

• Project/Area Number: 25462632
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Shinshu University
• Principal Investigator: FUKUOKA Hisakuni 信州大学, 医学部附属病院, 医員 (90419391)
• Co-Investigator(Renkei-kenkyūsha): USAMI Shin-ichi 信州大学, 学術研究院医学系, 教授 (10184996) ; TSUKADA Keita 信州大学, 学術研究院医学系(医学部附属病院), 助教 (90419375)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: メニエール病 / 画像診断 / 遺伝子 / 前庭機能 / SNPs

Outline of Final Research Achievements

The hallmark of Meniere’s disease (MD) is the confirmed presence of endolymphatic hydrops (ELH). We performed 3T MRI after a intratympanic injection of GBCAs (IT-Gd) contributes to an improved diagnosis and understanding of the pathological conditions in patients with MD. As a results, we revealed image-based diagnosis is expected to lead to revaluation and reclassification of the diagnostic criteria for MD and ELH-related diseases, such as DEH.