| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The cochlea in mammals is the well-ordered and beautiful organ for hearing. This research project is trying to elucidate the molecular regulation of sensory epithelium development in mammalian cochleae, and has both scientific and clinical importance. This is because the cochlear sensory epithelium sensitively exhibits the disorders caused by disturbance of cellular differentiation and tissue organization. Ultimately, better knowledge of how the mechanosensory hair cells in the cochlear sensory epithelium develop may form the basis for auditory hair cell regeneration. This research project revealed the roles and the crosstalk of Hedgehog, FGF and Notch signaling pathways in developing cochlear sensory epithelium by manipulation of these signaling pathways in vivo and ex vivo.
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