Regulation of sensory epithelium development in mammalian cochleae: a basis for auditory hair cell regeneration
| Project/Area Number |
25462635
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kyoto University |
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Principal Investigator |
Tateya Tomoko 京都大学, 白眉センター(ウイルス研究所), 特定助教 (10512311)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 蝸牛有毛細胞 / cochlea / inner hair cell / outer hair cell / supporting cell / differentiation / hair cell / development |
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| Outline of Final Research Achievements |
The cochlea in mammals is the well-ordered and beautiful organ for hearing. This research project is trying to elucidate the molecular regulation of sensory epithelium development in mammalian cochleae, and has both scientific and clinical importance. This is because the cochlear sensory epithelium sensitively exhibits the disorders caused by disturbance of cellular differentiation and tissue organization. Ultimately, better knowledge of how the mechanosensory hair cells in the cochlear sensory epithelium develop may form the basis for auditory hair cell regeneration. This research project revealed the roles and the crosstalk of Hedgehog, FGF and Notch signaling pathways in developing cochlear sensory epithelium by manipulation of these signaling pathways in vivo and ex vivo.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Hedgehog signaling regulates prosensory cell properties during the basal-to-apical wave of hair cell differentiation in the mammalian cochlea2013
Author(s)
Tateya, T., Imayoshi, I., Tateya, I., Hamaguchi, K., Torii, H., Ito, J., and Kageyama, R.
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Journal Title
Development
Volume: 140
Issue: 18
Pages: 3848-3857
DOI
Related Report
Peer Reviewed
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