| Project/Area Number |
25462639
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Nara Medical University (2015)
Osaka University (2013) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IMAI TAKAO 大阪大学, 医学(系)研究科(研究院), 講師 (80570663)
OTA YUMI 大阪大学, 医学(系)研究科(研究院), 助教 (00598401)
MORIHANA TETSUO 大阪大学, 医学(系)研究科(研究院), 助教 (80634170)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 耳鳴 / 逃避行動 / TRPファミリー / 侵害受容体 / サリチル酸 / 動物モデル / 神経栄養因子 / 内耳障害 |
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| Outline of Final Research Achievements |
Due to moving from Osaka University to Nara Medical University, we established the animal behavioral model for tinnitus again. Salicylate-induced tinnitus in rats could be visualized by behavioral and molecular experiments. Behavioral experiments were performed using an active avoidance task and molecular experiments were performed using a nociceptive receptor, transient receptor potential cation channel superfamily V (TRPV) in the rat auditory pathway. By means of these tinnitus visualization experiments, capsazepine, a specific antagonist of TRPV1, could be one of candidates to block tinnitus pathway and cure tinnitus. Further additional experiments are required.
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