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Molecular biological research for the protection and treatment of age related inner ear disorders by controlling of various ageing factors

Research Project

Project/Area Number 25462643
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionHiroshima University

Principal Investigator

TAKUMIDA MASAYA  広島大学, 大学病院, 講師 (00179590)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords内耳 / 老人性難聴 / めまい / サーチュイン / アクアポリン / ヒスタミン受容体 / 治療 / フリーラジカル / バゾプレッシン
Outline of Final Research Achievements

The purpose of the present study is the prevention and treatment of age-related inner ear disorder. Basically, distributions and functions of sirtuin, aquaporin and the histamine receptor in the inner ear have been revealed. Changes of these proteins due to aging have been also clarified. I have also developed a new animal model with endolymphatic hydrops and vertigo by the long-term administration of vasopressin, and clarified the relationship between the pathogenesis of attacks of vertigo and melanin. Additionally, latanoprost inhibited the development of endolymphatic hydrops. In order to clarify the cerebral cortex response during foam posturography in the elder people, NIRS was used. As a result, activation in the temporal-parietal areas was observed when the somatosensory information is reduced from the normal. Clinically, I showed the possibility of the prevention and treatment for the age-related balance disorders as with age-related hearing loss.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (14 results)

All 2016 2015 2014 2013 Other

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Acknowledgement Compliant: 3 results) Presentation (5 results) (of which Int'l Joint Research: 1 results) Remarks (2 results)

  • [Journal Article] Localization of histamine (H1, H2, H3 and H4) receptors in mouse inner ear2016

    • Author(s)
      Takumida M, Takumida H, Anniko M
    • Journal Title

      Acta Otolaryngol

      Volume: 134 Issue: 6 Pages: 537-544

    • DOI

      10.3109/00016489.2015.1136433

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Localization of sirtuins (SIRT1-7) in the aged mouse inner ear2016

    • Author(s)
      Takumida M, Takumida H, Katagiri Y, Anniko M
    • Journal Title

      Acta Otolaryngol

      Volume: 136 Issue: 2 Pages: 120-131

    • DOI

      10.3109/00016489.2015.1093172

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 加齢性難聴を認めた高齢者の平衡機能の薬物療法による変化-preliminary study2015

    • Author(s)
      工田昌也、片桐佳明
    • Journal Title

      Equilibrium Res

      Volume: 74 Pages: 266-273

    • NAID

      130005101956

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Localization of sirtuins in the mouse inner ear2014

    • Author(s)
      Takumida M, Takumida H, Anniko M
    • Journal Title

      Acta Otolaryngol

      Volume: 134 Issue: 4 Pages: 331-338

    • DOI

      10.3109/00016489.2013.861928

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Long-term administration of vasopressin can cause Meniere’s disease in mice2014

    • Author(s)
      Katagiri Y, Takumida M, Hirakawa K, Anniko M
    • Journal Title

      Acta Otolaryngol

      Volume: 134

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Localization of aquaporins in the mouse vestibular endorgans2013

    • Author(s)
      Takumida M, Takumida H, Kakigi K, Egami N, Nishioka R, Anniko M
    • Journal Title

      Acta Otolaryngol

      Volume: 133 Issue: 8 Pages: 804-813

    • DOI

      10.3109/00016489.2013.783717

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] バゾプレッシン2型受容体とアクアポリンの内耳内局在2013

    • Author(s)
      工田昌也
    • Journal Title

      生体の科学

      Volume: 64 Pages: 396-397

    • Related Report
      2013 Research-status Report
  • [Presentation] 長寿遺伝子(SIRT1-7)の内耳での局在と加齢による変化2015

    • Author(s)
      工田昌也、片桐佳明、平川勝洋
    • Organizer
      第74回めまい平衡医学会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-11-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] A new murine model for Meniere’s disease –vasopressin induced endolymphatic hydrops2015

    • Author(s)
      Takumida M, Katagiri Y, Anniko M
    • Organizer
      7th International Symposium on Meniere’s Disease and Inner Ear Disease
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2015-10-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of latanoprost on endolymphatic hydrops in an animal model2014

    • Author(s)
      Rask-Andersen H, Katagiri Y, Anniko M, Takumida M
    • Organizer
      16th International Symposium on Inner Ear Medicine and Surgery
    • Place of Presentation
      Zell Im Zillertal, Austria
    • Related Report
      2013 Research-status Report
  • [Presentation] メニエール病の難聴に対する当帰芍薬散の効果2013

    • Author(s)
      工田昌也、片桐佳明、平川勝洋
    • Organizer
      第72回日本めまい平衡医学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] 小児良性発作性めまい症と考えられた4症例2013

    • Author(s)
      片桐佳明、工田昌也、平川勝洋
    • Organizer
      第72回日本めまい平衡医学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Remarks] 広島大学 統合技術情報発信システム ひまわり

    • URL

      http://hutdb.hiroshima-u.ac.jp/seeds/view/784/ja

    • Related Report
      2015 Annual Research Report
  • [Remarks] 広島大学 統合技術情報発信システム ひまわり

    • URL

      http://hutdb.hiroshima-u.ac.jp/seeds/view/784/ja

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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