Molecular biological research for the protection and treatment of age related inner ear disorders by controlling of various ageing factors
| Project/Area Number |
25462643
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 内耳 / 老人性難聴 / めまい / サーチュイン / アクアポリン / ヒスタミン受容体 / 治療 / フリーラジカル / バゾプレッシン |
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| Outline of Final Research Achievements |
The purpose of the present study is the prevention and treatment of age-related inner ear disorder. Basically, distributions and functions of sirtuin, aquaporin and the histamine receptor in the inner ear have been revealed. Changes of these proteins due to aging have been also clarified. I have also developed a new animal model with endolymphatic hydrops and vertigo by the long-term administration of vasopressin, and clarified the relationship between the pathogenesis of attacks of vertigo and melanin. Additionally, latanoprost inhibited the development of endolymphatic hydrops. In order to clarify the cerebral cortex response during foam posturography in the elder people, NIRS was used. As a result, activation in the temporal-parietal areas was observed when the somatosensory information is reduced from the normal. Clinically, I showed the possibility of the prevention and treatment for the age-related balance disorders as with age-related hearing loss.
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Report
(3 results)
Research Products
(14 results)
