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HSV amplicon vector to treat facial nerve palsy

Research Project

Project/Area Number 25462650
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionNagoya City University

Principal Investigator

Murakami Shingo  名古屋市立大学, 医学(系)研究科(研究院), 教授 (80157750)

Co-Investigator(Kenkyū-buntansha) Hida Hideki  名古屋市立大学, 医学研究科, 教授 (00305525)
Hamajima Yuki  名古屋市立大学, 医学研究科, 講師 (30343403)
Esaki Shinichi  名古屋市立大学, 医学研究科, 助教 (20620983)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords顔面神経麻痺 / 単純ヘルペスウイルス / アンプリコンベクター / 肝細胞増殖因子 / HSV-1 / 神経栄養因子 / 神経再生
Outline of Final Research Achievements

Bell’s palsy is highly associated with diabetes mellitus (DM). Diabetes mellitus was induced with streptozotocin injection in only mice that developed transient facial nerve paralysis with HSV-1. Recurrent facial palsy was induced after HSV-1 reactivation by auricular scratch. After DM induction, the number of CD3+ T cells decreased by 70% in the DM mice, and facial nerve palsy recurred in 13% of the DM mice. HSV-1 DNA was detected in the facial nerve of all of the DM mice with palsy, and HSV-1 capsids were found in the geniculate ganglion using electron microscopy. These results suggested that HSV-1 reactivation in the geniculate ganglion may be the main causative factor of the increased incidence of facial paralysis in DM patients.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2015 2013

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results)

  • [Journal Article] Quantitative analysis of facial palsy using a three-dimensional facial motion measurement system.2015

    • Author(s)
      Katsumi S, Esaki S, Hattori K, Yamano K, Umezaki T, Murakami S.
    • Journal Title

      Auris Nasus Larynx.

      Volume: 42 Issue: 4 Pages: 275-283

    • DOI

      10.1016/j.anl.2015.01.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Facial nerve palsy after reactivation of herpes simplex virus type 1 in diabetic mice2015

    • Author(s)
      Esaki S, Yamano K, Katsumi S, Minakata T, Murakami S
    • Journal Title

      Laringoscope

      Volume: 125 Issue: 4

    • DOI

      10.1002/lary.24994

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Seasonal variation in a clinical referral pediatric cohort at risk for obstructive sleep apnea.2013

    • Author(s)
      Murakami S
    • Journal Title

      International Journal of Pediatric Otorhinolaryngology

      Volume: 77(2) Pages: 266-269

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Tumors: Decision Making and Surgical Treatment of Acoustic Schwannoma2015

    • Author(s)
      Shingo Murakami
    • Organizer
      30th Polizer Society Meeting
    • Place of Presentation
      朱鷺メッセ(新潟県、新潟市)
    • Year and Date
      2015-06-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ウイルス性顔面神経麻痺ー病態と後遺症克服のための新たな治療ー2015

    • Author(s)
      村上信五
    • Organizer
      第116回日本耳鼻咽喉科学会
    • Place of Presentation
      東京国際フォーラム(東京都、千代田区)
    • Year and Date
      2015-05-20
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Predictors of hearing preservation for microsurgery and radiosurgery and intraoperative monitoring2015

    • Author(s)
      Shingo Murakami
    • Organizer
      7th International Conference on Acoustic Neuroma
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2015-04-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Management of Facial paralysis2013

    • Author(s)
      Murakami S
    • Organizer
      2nd Meeting of European Academy of ORL-HNS and CE ORL-HNS
    • Place of Presentation
      Acropolis Conference Centre(ニース,フランス)
    • Related Report
      2013 Research-status Report
  • [Presentation] Recovery of conduction block after facial nerve decompression2013

    • Author(s)
      Murakami S
    • Organizer
      12th Facial Nerve SYMPOSIUM
    • Place of Presentation
      THE LIIIBERTY HOTEL (ボストン,アメリカ)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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