HSV amplicon vector to treat facial nerve palsy
| Project/Area Number |
25462650
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Nagoya City University |
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Principal Investigator |
Murakami Shingo 名古屋市立大学, 医学(系)研究科(研究院), 教授 (80157750)
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| Co-Investigator(Kenkyū-buntansha) |
Hida Hideki 名古屋市立大学, 医学研究科, 教授 (00305525)
Hamajima Yuki 名古屋市立大学, 医学研究科, 講師 (30343403)
Esaki Shinichi 名古屋市立大学, 医学研究科, 助教 (20620983)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 顔面神経麻痺 / 単純ヘルペスウイルス / アンプリコンベクター / 肝細胞増殖因子 / HSV-1 / 神経栄養因子 / 神経再生 |
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| Outline of Final Research Achievements |
Bell’s palsy is highly associated with diabetes mellitus (DM). Diabetes mellitus was induced with streptozotocin injection in only mice that developed transient facial nerve paralysis with HSV-1. Recurrent facial palsy was induced after HSV-1 reactivation by auricular scratch. After DM induction, the number of CD3+ T cells decreased by 70% in the DM mice, and facial nerve palsy recurred in 13% of the DM mice. HSV-1 DNA was detected in the facial nerve of all of the DM mice with palsy, and HSV-1 capsids were found in the geniculate ganglion using electron microscopy. These results suggested that HSV-1 reactivation in the geniculate ganglion may be the main causative factor of the increased incidence of facial paralysis in DM patients.
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Report
(3 results)
Research Products
(8 results)
