Resting-state fMRI study and central regulation against auditory abnormal sensation and
| Project/Area Number |
25462657
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | 独立行政法人国立病院機構(東京医療センター臨床研究センター) |
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Principal Investigator |
Minami Shujiro 独立行政法人国立病院機構(東京医療センター臨床研究センター), 聴覚平衡覚研究部, 医長 (00399544)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脳機能画像 / 耳鳴 / 安静時fMRI / 機能的結合 / 聴覚関連領域 / 経頭蓋直流電気刺激 / 聴覚異常感 / 聴覚野 / 苦痛ネットワーク / 聴覚視床皮質発火リズム変調 |
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| Outline of Final Research Achievements |
The purpose of this study is to investigate brain functional connectivity in tinnitus patients. and to develop objective diagnosis for tinnitus. Nineteen volunteers with normal hearing, 11 tinnitus patients without hearing loss, and 18 tinnitus patients with hearing loss were enrolled in this study. The subjects were evaluated with resting-state fMRI.
With a beta threshold of >0.5, 30% of all possible connections between auditory-related ROIs in the control group remained intact, whereas only 14% and 3% of such connections were present in the tinnitus groups. Between non-auditory-related ROIs, the rates of intact connections at a beta threshold of >0.5 were 3% in the control group and 3% and 2% in the tinnitus groups. The levels of functional connectivity between auditory-related regions were lower in the tinnitus group than in the control group. The data suggest that the associations between auditory-related networks are weakened in tinnitus patients, even if they have normal hearing.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] GJB2-associated hearing loss undetected by hearing screening of newborns2013
Author(s)
Shujiro B Minami, Hideki Mutai, Atsuko Nakano, Yukiko Arimoto, Hidenobu Taiji, Noriko Morimoto, Hideaki Sakata, Nodoka Adachi, Sawako Masuda, Hirokazu Sakamoto, Haruo Yoshida, Fujinobu Tanaka, Tomoko Sugiuchi, Kimitaka Kaga, Tatsuo Matsunaga
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Journal Title
GENE
Volume: 532
Issue: 1
Pages: 41-45
DOI
Related Report
Peer Reviewed
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[Presentation] Microbiome in normal middle ear and chronic otitis media2015
Author(s)
Shujiro B. Minami, Hideki Mutai, Arai Horii, Koichiro Wasano, Motoyasu Katsura, Fujinobu Tanaka, Tetsuya Takiguchi, Naoki Oishi, Masato Fujii, Kimitaka Kaga
Organizer
10th Asia Pacific Symposium on Cochlear Implant
Place of Presentation
中国 北京
Year and Date
2015-05-01
Related Report
Int'l Joint Research
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