Stereological quantification of the total olfactory receptor neurons in the olfactory epithelium.

Research Project

Project/Area Number	25462661
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Otorhinolaryngology
Research Institution	Shinshu University
Principal Investigator	KAWAGISHI Kyutaro 信州大学, 学術研究院医学系, 助教 (40313845)
Co-Investigator(Kenkyū-buntansha)	FUKUSHIMA Nanae 信州大学, 学術研究院医学系, 准教授 (90334888)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	嗅神経 / 神経総数 / 神経解剖 / 嗅覚
Outline of Final Research Achievements	The total number of olfactory marker protein (OMP) positive olfactory receptor neurons in the unilateral olfactory epithelium of adult mice was estimated by using stereology method.The number was approximately 5,000,000 in adult C57BL/6J mice. Corresponding neuronal numbers were also estimated in newborn and adult Wistar rats. The numbers were approximately 500,000 in newborn rats and approximately 21,000,000 in 8 weeks old adult rats. In adult rats, the numbers of olfactory receptor neurons remained unchanged until 2 years old.