Development of the method of measurement of amyloid-beta in nasal samples for diagnosis of Alzheimer's Disease

• Project/Area Number: 25462663
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Shimizu Shino 滋賀医科大学, 医学部, 医員 (50505592)
• Co-Investigator(Kenkyū-buntansha): SHIMIZU Takeshi 滋賀医科大学, 医学部, 教授 (00206202) ; TOOYAMA Ikuo 滋賀医科大学, 分子神経科学研究センター, 教授 (20207533)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: アルツハイマー病 / 早期診断 / ヒト鼻腔 / アミロイドβ / タウ蛋白 / 嗅粘膜

Outline of Final Research Achievements

We have shown that we can detect significant concentration of amyloid-beta or Tau protein in human nasal cavity samples. We have reported the method to measure amyloid-beta in nasal cavity samples. Moreover, we had a clinical study for diagnosis of Alzheimer's Disease using nasal cavity samples. The data of the clinical study are under analysis.

Research Products

• [Presentation] Improved precision of Aβ measurements in nasal samples using a new collection instrument. (2013)
  • Author(s): Toshifumi Nanjo, Takaomi Fukuhara, Naoko Kameshima et al.
  • Organizer: Alzheimer's Association International Conference 2013
  • Place of Presentation: Boston, USA
• [Remarks] 鼻腔内検体を用いた認知症診断法に関する臨床研究（１）について
  • URL: http://ben.shiga-med.ac.jp/~hqmnran/
• [Patent(Industrial Property Rights)] 採取パーツと採取パーツを備える生体組織採取具 (2014)
  • Inventor(s): 南條俊文、福原崇臣、濱中健一、遠山育夫、清水志乃
  • Industrial Property Rights Holder: パナソニックヘルスケア株式会社
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2014-011126
  • Filing Date: 2014
• [Patent(Industrial Property Rights)] 生体組織採取器具 (2014)
  • Inventor(s): 森分優太、篠原紀行、南條俊文、濱中健一、遠山育夫、清水志乃等
  • Industrial Property Rights Holder: パナソニックヘルスケア株式会社
  • Industrial Property Rights Type: 意匠
  • Filing Date: 2014