Development of the method of measurement of amyloid-beta in nasal samples for diagnosis of Alzheimer's Disease
| Project/Area Number |
25462663
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
Shimizu Shino 滋賀医科大学, 医学部, 医員 (50505592)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMIZU Takeshi 滋賀医科大学, 医学部, 教授 (00206202)
TOOYAMA Ikuo 滋賀医科大学, 分子神経科学研究センター, 教授 (20207533)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | アルツハイマー病 / 早期診断 / ヒト鼻腔 / アミロイドβ / タウ蛋白 / 嗅粘膜 |
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| Outline of Final Research Achievements |
We have shown that we can detect significant concentration of amyloid-beta or Tau protein in human nasal cavity samples. We have reported the method to measure amyloid-beta in nasal cavity samples. Moreover, we had a clinical study for diagnosis of Alzheimer's Disease using nasal cavity samples. The data of the clinical study are under analysis.
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Report
(3 results)
Research Products
(4 results)
