| Project/Area Number |
25462668
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
UNO Keisuke 東京慈恵会医科大学, 耳鼻咽喉科学講座, 講師 (90629544)
大櫛 哲史 東京慈恵会医科大学, 医学部, 講師 (50317939)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ILC2 / 自然リンパ球 / 好酸球 / 好酸球性副鼻腔炎 / 慢性副鼻腔炎 / IL-5 / IL-33 / IL-13 / 非好酸球性副鼻腔炎 / Innate immunity / 自然免疫 / 好酸球性鼻副鼻腔炎 / ECRS |
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| Outline of Final Research Achievements |
We hypothesized that ILC2s are enriched in blood and nasal polyps in patients with eosinophilic chronic rhinosinusitis (ECRS) and are associated with its pathology.EDN and Th2 cytokines are significantly higher in ECRS than non-ECRS (NECRS). EDN had strongly correlated with the numbers of ILC2s in NPs. The counts of ILC2s in NPs were significantly higher in ECRS than NECRS. Immunostained ILC2 were showed accumulated in nasal polyps of ECRS, but not in NECRS or normal subjects. ILC2’s CD25 surface expression in PBMC was significantly higher in ECRS than NECRS. ILC2’s IL-17RB surface expression in NPs was significantly higher in NECRS than ECRS. Lineage negative cells from ECRS’ NP, but not from NECRS’, produced IL-5 and IL-13 in both IL-2 and IL-33 stimulation.
ILC2 are considered as candidate of the commander in ECRS, which strongly induce Th2 inflammation. There are possibility that ILC2s have several subtypes and the characteristic of ILC2s are differ from their environment.
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