Elucidation of the pathology of neurogenic olfactory disorder and its application to therapy
| Project/Area Number |
25462669
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
MIWA Takaki 金沢医科大学, 医学部, 教授 (20229909)
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| Co-Investigator(Kenkyū-buntansha) |
山本 純平 金沢医科大学, 医学部, 助教 (20460371)
志賀 英明 金沢医科大学, 医学部, 准教授 (80436823)
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| Research Collaborator |
NODA Takuya 金沢医科大学, 医学部, 助教 (00722662)
YAMADA Kentaro 金沢医科大学, 医学部, 助教 (60722642)
HARITA Masayuki 金沢医科大学, 医学部, 助教 (40769105)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 嗅神経 / 再生 / エストロゲン / 神経成長因子 / 卵巣摘出 / 女性 / マウス / 当帰芍薬散 / 感冒後嗅覚障害 / エストラジオール / 嗅覚障害 / 卵巣除去 |
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| Outline of Final Research Achievements |
Upper respiratory tract infections are a frequent cause of olfactory dysfunction. Typically, women are affected more frequently than men, and are middle aged or older at presentation. Although, the reason of them is uncertain, but they may be due to the reduced regenerative ability of the olfactory system with advancing age in female. To know the correlation between regenerative ability of olfactory neuron and estrogen, we used olfactory nerve destroyed mice using methimazole. Regeneration of olfactory neuron after degeneration was delayed in ovariectomized female mice than in sham-ope mice or male mice. It is suspected that decrease of estrogen influence regeneration of olfactory neuron.
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Report
(4 results)
Research Products
(26 results)
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[Presentation] 当帰芍薬散の嗅神経再生効果の検討2017
Author(s)
能田拓也, 志賀英明, 張田雅之, 山田健太郎, 三輪高喜, 二宮英明
Organizer
第35回日本耳鼻咽喉科免疫アレルギー学会
Place of Presentation
旭川グランドホテル（北海道旭川市）
Year and Date
2017-04-13
Related Report
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[Presentation] TOPICAL THERAPIES2016
Author(s)
T Miwa
Organizer
26th Congress of the european rhinologic society
Place of Presentation
Stockholm Waterfront Congress Centre（スウェーデンストックホルム）
Year and Date
2016-07-03
Related Report
Int'l Joint Research / Invited
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[Presentation] 嗅覚障害と漢方治療2016
Author(s)
志賀英明, 能田拓也, 山田健太郎, 張田雅之, 中村有加里, 平場友子, 熊井理美, 山本純平, 三輪高喜
Organizer
第32回日本耳鼻咽喉科漢方研究会
Place of Presentation
The Grand Hall（東京都港区）
Related Report
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