| Project/Area Number |
25462671
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Hyogo Medical University |
|---|
Principal Investigator |
Tsuzuki Kenzo 兵庫医科大学, 医学部, 准教授 (50441308)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KATSURA Hirokazu 兵庫医科大学, 医学部, 講師 (90533761)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 慢性副鼻腔炎 / 好酸球性副鼻腔炎 / 嗅覚障害 / メントール / 膝神経節 / アレルギー性鼻炎 / 内視鏡スコア / 鼓索神経 |
|---|
| Outline of Final Research Achievements |
We studied about patients with chronic rhinosinusitis (CRS) in the pre-, intra-, and postoperative stages for endoscopic sinus surgery (ESS). Olfaction were investigated using a test for research including menthol as smells item, T&T recognition threshold test, and intravenous olfaction test. We proposed a novel scoring for operating findings during ESS according to mucosal condition and sinus contents. We, further, reported a novel scoring for postoperative endoscopic endonasal findings (E score), and evaluated its variability and usefulness. We reported that olfactory disorder and E scores in patients with eosinophilic CRS (ECRS) were significantly worse than those in patients with non-ECRS. We found that decreased expression levels of transient receptor potential vanilloid 1 (TRPV1) and transient receptor potential melastatin 8 (TRPM8) in uninjured neurons in ipsilateral rat geniculate ganglion (GG) after chorda tympani nerve injury.
|
