Development of new therapeutic strategies of hypopharyngeal cancer based on the RNA network analysis
| Project/Area Number |
25462676
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Chiba University |
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Principal Investigator |
KIKKAWA Naoko 千葉大学, 医学部附属病院, 特任助教 (50400924)
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| Co-Investigator(Kenkyū-buntansha) |
HANAZAWA Toyoyuki 千葉大学, 大学院医学研究院, 准教授 (90272327)
SEKI Naohiko 千葉大学, 大学院医学研究院, 准教授 (50345013)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | マイクロＲＮＡ / 頭頸部扁平上皮癌 / 下咽頭癌 / miR-504 / CDK6 / マイクロRNA / がん抑制遺伝子 / ｍｉｃｒｏＲＮＡ |
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| Outline of Final Research Achievements |
Despite of considerable advances in multimodality therapy, the overall 5-year survival rate for patients with hypopharyngeal squamous cell carcinoma (HSCC) is ranging from 30-40%. To date, there is no effective treatment resumes for patients with recurrence and distant metastasis of HSCC. Our recent study of microRNA (miRNA) expression signature of HSCC showed that miR-504 was significantly reduced in cancer tissues. Ectopic expression of miR-504 markedly suppressed cancer cell proliferation. To identify the molecular targets of miR-504, cell cycle-related genes were selected as target genes of miR-504. The expression of cyclin-dependent kinase 6 (CDK6) was significantly higher in HSCC tissues compared to non-cancer tissues. Expression of miR-504 inhibited CDK6 expression in HSCC cells. The identification of target oncogenes regulated by miR-504 might lead to a better understanding of HSCC pathogenesis the development of new therapeutic strategies to treat this disease.
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] Tumor-suppressive microRNAs (miR-26a/b, miR-29a/b/c and miR-218) concertedly suppressed metastasis-promoting LOXL2 in head and neck squamous cell carcinoma2016
Author(s)
Ichiro Fukumoto, Naoko Kikkawa, Ryosuke Matsushita, Mayuko Kato, Akira Kurozumi, Rika Nishikawa, Yusuke Goto, Keiichi Koshizuka, Toyoyuki Hanazawa, Hideki Enokida, Masayuki Nakagawa, Yoshitaka Okamoto, Naohiko Seki
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Journal Title
Journal of Human Genetics
Volume: 61(2)
Issue: 2
Pages: 109-118
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] MicroRNA expression signature of oral squamous cell carcinoma: functional role of microRNA-26a/b in the modulation of novel cancer pathways.2015
Author(s)
Fukumoto I, Hanazawa T, Kinoshita T, Kikkawa N, Koshizuka K, Goto Y, Nishikawa R, Chiyomaru T, Enokida H, Nakagawa M, Okamoto Y, Seki N.
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Journal Title
Br J Cancer
Volume: 112
Issue: 5
Pages: 891-900
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Identification of tumour suppressive microRNA-451a in hypopharyngeal squamous cell carcinoma based on microRNA expression signature2014
Author(s)
Fukumoto I, Kinoshita T, Hanazawa T, Kikkawa N, Chiyomaru T, Enokida H, Yamamoto N, Goto Y, Nishikawa R, Nakagawa M, Okamoto Y, Seki N.
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Journal Title
British Journal of Cancer
Volume: 111
Issue: 2
Pages: 386-394
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] microRNA-504 inhibits cancer cell proliferation via targeting CDK6 in hypopharyngeal squamous cell carcinoma.2014
Author(s)
Kikkawa N, Kinoshita T, Nohata N, Hanazawa T, Yamamoto N, Fukumoto I, Chiyomaru T, Enokida H, Nakagawa M, Okamoto Y, Seki N.
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Journal Title
Int J Oncol
Volume: 44
Pages: 2085-92
Related Report
Peer Reviewed
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