The significance of bcl-2 in production of galactose-deficient IgA1 in IgA nephropathy
Project/Area Number |
25462678
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Otorhinolaryngology
|
Research Institution | University of Fukui |
Principal Investigator |
SUNAGA HIROSI 福井大学, 医学部, 特別研究員 (30362049)
|
Co-Investigator(Kenkyū-buntansha) |
FUJIEDA SHIGEHARU 福井大学, 医学部, 教授 (30238539)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | IgA腎症 / 口蓋扁桃 / 病巣感染症 / 糖鎖不全IgA / 粘膜免疫 / bcl-2 / リンパ球 / siRNA / Haemophilus / parainfluenzae / Bcl-2 |
Outline of Final Research Achievements |
In this study, we demonstrated that the level of bcl-2 was significantly increased in tonsil mononuclear cells from the patients with IgA nephropathy compare to control sample. In peripheral mononuclear cells, the level of bcl-2 was also increased, significantly. Since galactose-deficient IgA1 is involved in pathogenesis of IgA nephropathy, our results suggest that bcl-1 might play pivotal role in production of galactose-deficient IgA1. We therefore study the influences of bcl-2 on production of galactose-deficient IgA1. Stimulation of lipopolysaccharide (LPS) or H. Parainfluenzae (HP antigen) on peripheral mononuclear cells induce up-regulation of galactose-deficient IgA1 in supernatant by using ELISA. However, suppression of bcl-2 did not influence the production of galactose-deficient IgA1. Therefore, we could not any correlation between bcl-2 and galactose-deficient IgA1. Further study is required to elucidate the mechanism by which bcl-2 induce IgA nephropathy.
|
Report
(4 results)
Research Products
(1 results)