Polymeric Micelle for a Novel Nano-Medicine Therapy Against Head and Neck Cancer

Research Project

Project/Area Number	25462690
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Otorhinolaryngology
Research Institution	The University of Tokyo (2016-2017) 独立行政法人国立病院機構(東京医療センター臨床研究センター) (2013-2015)
Principal Investigator	Kimura Miwako 東京大学, 医学部附属病院, 登録研究員 (00376435)
Project Period (FY)	2013-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	ドラッグデリバリーシステム / 頭頚部腫瘍 / 頭頸部腫瘍 / 高分子型ミセル / ミセル
Outline of Final Research Achievements	2013-2014: The orthotopic hypopharyngeal tumor mouse model was established using the human hypopharyngeal carcinoma-derived FaDu cell line. The luciferase-stable FaDu cell line was also acquired. IVIS (in vivo bioluminescence/fluorescence imaging system) were utilized to monitor the hypopharyngeal tumor model during cell engraftment, tumor progression, and treatment response. 2014-2015: Maternity and parental leave. 2016-2017: Tailor-maid drug delivery system was developed by ligand-functionalized polymeric micelles. Tumor accumulation and anti-tumor activity of the micelle was assessed using the IVIS. Pharmacokinetics and tumor distribution of the micelle was investigated using the intravital confocal laser scanning microscopy.