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cancer-related small RNA as a biomarker for head and neck cancer

Research Project

Project/Area Number 25462691
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionKyorin University (2015)
Keio University (2013-2014)

Principal Investigator

Saito Koichiro  杏林大学, 医学部, 教授 (40296679)

Co-Investigator(Kenkyū-buntansha) IWAMARU Arifumi  慶應義塾大学, 医学部, 研究員 (00296592)
ZAMA Takeru  慶應義塾大学, 医学部, 特任講師 (30296719)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords頭頸部癌 / 診断 / 治療 / 頭頸部腫瘍 / 遺伝子
Outline of Final Research Achievements

In this study, we have found that miR-196a could be a potential diagnostic biomarker for laryngeal cancer. Furthermore, results of our study suggested that this miR could be a promising future diagnostic target to treat laryngeal cancer.
Furthermore, we have investigated the human papillomvirus (HPV) expression in laryngeal papilloma. We found expressions of several unique HPV subtypes in laryngeal papilloma tissues. We further assessed the HPV subtypes combined with our abundant clinical background data of the patients, and found several promising findings. These unique and promising results offered multiple opportunities for us to present our data in Japan and US.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (25 results)

All 2016 2015 2014 2013 Other

All Journal Article (9 results) Presentation (12 results) (of which Invited: 4 results) Book (2 results) Remarks (2 results)

  • [Journal Article] 【咽喉頭異常感の疑問に答える】 咽喉頭異常感をきたす機序を教えてください2015

    • Author(s)
      齋藤康一郎、宇野光祐
    • Journal Title

      JOHNS

      Volume: 31 Pages: 5-10

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 【長引く咳を診る】 疾患別 咳の診かた 喉頭疾患による咳2015

    • Author(s)
      齋藤康一郎
    • Journal Title

      耳鼻咽喉科・頭頸部外科

      Volume: 87 Pages: 798-801

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 喉頭良性疾患の診断と治療2015

    • Author(s)
      齋藤康一郎
    • Journal Title

      日本耳鼻咽喉科学会会報

      Volume: 118 Pages: 894-897

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 【耳鼻咽喉科薬物療法2015】 耳鼻咽喉科の疾患・症候別薬物療法 喉頭乳頭腫2015

    • Author(s)
      齋藤康一郎
    • Journal Title

      JOHNS

      Volume: 31 Pages: 1346-1348

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 【小児耳鼻咽喉科診療における論点】 喉頭乳頭腫はどのように治療するか? 手術的治療の立場から2015

    • Author(s)
      大久保啓介、齋藤康一郎
    • Journal Title

      JOHNS

      Volume: 31 Pages: 1783-1786

    • Related Report
      2015 Annual Research Report
  • [Journal Article] ヒト乳頭腫ウイルス感染の現状と新しい展開 喉頭乳頭腫を巡る現状と現実的なアプローチ20132014

    • Author(s)
      齋藤康一郎
    • Journal Title

      日本耳鼻咽喉科学会誌

      Volume: 117 Pages: 614-630

    • Related Report
      2014 Research-status Report
  • [Journal Article] ここに注目! 知っているようで知らない疾患のトリセツ 喉頭がん2014

    • Author(s)
      齋藤康一郎
    • Journal Title

      クレデンシャル(Credentials)

      Volume: 64 Pages: 12-13

    • Related Report
      2014 Research-status Report
  • [Journal Article] ここに注目! 知っているようで知らない疾患のトリセツ 喉頭がん2014

    • Author(s)
      齋藤康一郎
    • Journal Title

      クレデンシャル

      Volume: 64 Pages: 12-13

    • Related Report
      2013 Research-status Report
  • [Journal Article] 専門医通信 喉頭乳頭腫の取り扱い2013

    • Author(s)
      齋藤康一郎
    • Journal Title

      日本耳鼻咽喉科学会会報

      Volume: 116 Pages: 1342-1343

    • Related Report
      2013 Research-status Report
  • [Presentation] 喉頭乳頭腫の臨床的取扱い2016

    • Author(s)
      齋藤康一郎
    • Organizer
      日本耳鼻咽喉科学会広島県地方部会研修会
    • Place of Presentation
      広島
    • Year and Date
      2016-02-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 喉頭乳頭腫の取り扱い2015

    • Author(s)
      齋藤康一郎
    • Organizer
      東京都耳鼻咽喉科医会 学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2015-12-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 喉頭疾患の診断、治療に関するup-to-date2015

    • Author(s)
      齋藤康一郎
    • Organizer
      杉並区耳鼻咽喉科専門医会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 喉頭乳頭腫への関わり方2015

    • Author(s)
      齋藤康一郎
    • Organizer
      第3回Airway Club Tama (多摩地区鼻疾患研究会)
    • Place of Presentation
      東京
    • Year and Date
      2015-10-31
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Unique Clinical Findings in Laryngeal Leukoplakia to Predict Serious Histopathology in Low-Risk Non-Smokers2014

    • Author(s)
      Kosuke Uno, Koichiro Saito, Takeyuki Kono, Haruna Yabe, Kaoru Ogawa
    • Organizer
      American Academy of Otolaryngology-Head and Neck Surgery Annual Meeting
    • Place of Presentation
      Orlando, FL, USA
    • Year and Date
      2014-09-21 – 2014-09-24
    • Related Report
      2014 Research-status Report
  • [Presentation] Demographic investigation of laryngeal leukoplakia in non-smokers -Predictors for serious pathology in the low-lisk group-2014

    • Author(s)
      Kosuke Uno, Koichiro Saito, Takeyuki Kono, Haruna Yage, Kaoru Ogawa
    • Organizer
      5th World Congress of IFHNOS (International Federation of Head and Neck Oncologic Societies) & Annual Meeting of the AHNS (American Head and Neck Society)
    • Place of Presentation
      New York City, NY, USA
    • Year and Date
      2014-07-26 – 2014-07-30
    • Related Report
      2014 Research-status Report
  • [Presentation] Laryngeal leukoplakia in non-smokers -who requires biopsy?-2014

    • Author(s)
      Kosuke Uno, Koichiro Saito, Takeyuki Kono, Haruna Yabe, Kaoru Ogawa
    • Organizer
      5th World Congress of IFHNOS (International Federation of Head and Neck Oncologic Societies) & Annual Meeting of the AHNS (American Head and Neck Society)
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2014-04-14 – 2014-04-16
    • Related Report
      2014 Research-status Report
  • [Presentation] シンポジウム 基礎「喉頭疾患とヒト乳頭腫ウイルス」2014

    • Author(s)
      齋藤康一郎
    • Organizer
      日本喉頭科学会
    • Place of Presentation
      沖縄
    • Related Report
      2013 Research-status Report
  • [Presentation] 喉頭乳頭腫症例の喉頭機能と音声に関するQOLの検討2014

    • Author(s)
      矢部はる奈、齋藤康一郎 他
    • Organizer
      日本気管食道科学会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 非喫煙者における声帯白色病変の臨床的検討2014

    • Author(s)
      宇野光祐、齋藤康一郎 他
    • Organizer
      日本音声言語医学会
    • Place of Presentation
      高知
    • Related Report
      2013 Research-status Report
  • [Presentation] シンポジウム1「人乳頭腫ウイルス感染の現状と新しい展開」2014

    • Author(s)
      齋藤康一郎
    • Organizer
      日本耳鼻咽喉科学会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] 当科における喉頭乳頭腫の臨床的検討2014

    • Author(s)
      矢部はる奈、齋藤康一郎 他
    • Organizer
      日本耳鼻咽喉科学会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
  • [Book] 慶應義塾大学病院の医師100人と学ぶ病気の予習帳2015

    • Author(s)
      塚崎朝子
    • Publisher
      講談社
    • Related Report
      2015 Annual Research Report
  • [Book] ENT臨床フロンティア2013

    • Author(s)
      久育男 編 第4章 齋藤康一郎
    • Publisher
      中山書店
    • Related Report
      2013 Research-status Report
  • [Remarks] 慶應義塾大学医学部 耳鼻咽喉科学教室

    • URL

      http://www.keio-ent.jp/

    • Related Report
      2014 Research-status Report
  • [Remarks] 慶應義塾大学医学部 耳鼻咽喉科学教室

    • URL

      http://www.keio-ent.jp/

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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