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A novel lymphatic chemotherapy targeting metastatic lymph nodes in patients with head and neck cancer using anti-cancer drugs combined with micelle

Research Project

Project/Area Number 25462693
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionKyorin University (2014-2015)
Juntendo University (2013)

Principal Investigator

Junkichi Yokoyama  杏林大学, 医学部, 非常勤講師 (60312584)

Co-Investigator(Kenkyū-buntansha) Hasegawa Yasuhisa  愛知県立がんセンター, 研究所, その他 (10261207)
Ohba Shinichi  順天堂大学, 医学部, 准教授 (20549274)
Ikeda Katuhisa  順天堂大学, 医学部, 教授 (70159614)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsリンパ管化学療法 / センチネルリンパ節 / 低侵襲治療 / ドラッグデリバリーシステム / targeting Chemotherapy / navigation surgery / ICG蛍光法 / Targeting chemotherapy / Navigation surgery
Outline of Final Research Achievements

Neck lymph node metastasis is the most significant prognostic factor of head and neck cancer. According to the Sentinel theory, metastatic lymph nodes are directly connected with primary tumors via lymphatic canals. Lymphatic chemotherapy is defined as chemotherapy using lymphatic canals between metastatic lymph nodes and primary tumors. As an ultimate cancer treatment which is both highly effective and noninvasive, the current study is to establish a novel lymphatic chemotherapy targeting metastatic lymph nodes in patients with head and neck cancer using anti-cancer drugs combined with micelle. The ICG fluorescence imaging effectively reveals the lymphatic vessels to the metastatic lymph nodes in real time.
We have evaluated the usefulness of lymphatic chemotherapy targeting neck metastases in patients with head and neck cancer by measuring CDDP concentrations in metastatic lymph nodes and pathological effects

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (47 results)

All 2016 2015 2014 2013

All Journal Article (29 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 29 results,  Open Access: 18 results,  Acknowledgement Compliant: 20 results) Presentation (15 results) (of which Invited: 3 results) Book (3 results)

  • [Journal Article] Primary Tumor-Secreted Lymphangiogenic Factors Induce Pre-Metastatic Lymphvascular Niche Formation at Sentinel Lymph Nodes in Oral Squamous Cell Carcinoma2015

    • Author(s)
      2: Wakisaka N, Hasegawa Y, Yoshimoto S, Miura K, Shiotani A, Yokoyama J, Sugasawa M, Moriyama-Kita M, Endo K, Yoshizaki T
    • Journal Title

      PLoS One

      Volume: 10 Issue: 12 Pages: e0144056-e0144056

    • DOI

      10.1371/journal.pone.0144056

    • NAID

      120005743890

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Minimally Invasive Transoral Surgical Treatment for Oropharyngeal Carcinoma.2015

    • Author(s)
      J Yokoyama, S Ohba, M Kojima, et al.
    • Journal Title

      Current Cancer Therapy Reviews

      Volume: 11 Issue: 1 Pages: 21-26

    • DOI

      10.2174/1573394711666150428003125

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Rapidly Increasing Trends in Oropharyngeal Carcinoma Assessed by Worldwide Epidemiologic Analysis.2015

    • Author(s)
      Enyinnaya Ofo, J Yokoyama.
    • Journal Title

      Current Cancer Therapy Reviews

      Volume: 11 Issue: 1 Pages: 15-20

    • DOI

      10.2174/1573394711666150428003039

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Epoch-making Treatment with Transoral Robotic Surgery for Oropharyngeal Carcinoma.2015

    • Author(s)
      A Shimizu, M Suzuki, S Krishnan and J Yokoyama
    • Journal Title

      Current Cancer Therapy Reviews

      Volume: 11 Issue: 1 Pages: 27-32

    • DOI

      10.2174/1573394711666150428002953

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Chemoradiation for Oropharyngeal Carcinoma for Organ Preservation.2015

    • Author(s)
      S Ohba, J Yokoyama, M Kojima and M Sakai.
    • Journal Title

      Current Cancer Therapy Reviews

      Volume: 11 Issue: 1 Pages: 33-37

    • DOI

      10.2174/1573394711666150428003349

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel procedure combining transoral resection and set-back tongue flap for oropharyngeal cancer2015

    • Author(s)
      M Sakai, J Yokoyama, et al.
    • Journal Title

      Acta Oto-Laryngologica

      Volume: 135 Issue: 7 Pages: 736-40

    • DOI

      10.3109/00016489.2015.1011790

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Cytological features of mammary analogue secretory carcinoma of the parotid gland in a 15-year-old girl.2015

    • Author(s)
      T Inaba, Y Fukumura, T Saito, J Yokoyama, et al.
    • Journal Title

      Case Reports in Pathology

      Volume: 10 Pages: 1-6

    • DOI

      10.1155/2015/656107

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Removing mastoid tip procedure for advanced parotid cancer results in easy identification of the facial nerve and adequate surgical margin.2015

    • Author(s)
      J Yokoyama, S Ohba, Shin I, M Fujimaki , M Kojima , K Ikeda .
    • Journal Title

      J Otol Rhinol

      Volume: 10S1:1

    • DOI

      10.4172/2324-8785.s1-007

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A novel functional reconstruction method for recurrent laryngeal cancer after vertical partial laryngectomy.2015

    • Author(s)
      S Ohba, J Yokoyama, M Fujimaki, S Ito, K Ikeda
    • Journal Title

      Journal of Otology & Rhinology

      Volume: S1 Pages: 11-11

    • DOI

      10.4172/2324-8785.s1-011

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A case of relapsing polychondritis diagnosed by biopsy of thyroid cartilage.2015

    • Author(s)
      D Sasaki, J Yokoyama, S Ohba, M Fujimaki, M Kojima, et al.
    • Journal Title

      J Otol Rhinol

      Volume: 10S1:1

    • DOI

      10.4172/2324-8785.s1-017

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Antegrade Bipedicled Submental Island Flap for Anterior Oropharyngeal Defect2015

    • Author(s)
      T Anzai, J Yokoyama, S Ohba, M Fujimaki, M Kojima , H Komatsu, S Ito, K Ikeda
    • Journal Title

      Journal of Otology & Rhinology

      Volume: S1 Pages: 16-16

    • DOI

      10.4172/2324-8785.s1-016

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Problems associated with vacuum-assisted closure system in postoperative head and neck fistula.2015

    • Author(s)
      M Kojima, J Yokoyama, S Ohba, M Fujimaki, et al
    • Journal Title

      J Otol Rhinol

      Volume: 10S1:1

    • DOI

      10.4172/2324-8785.s1-014

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Massive myoepithelial carcinoma originating from the submandibular gland that was successfully treated with surgical excision using a part of the lengthened skin as a local flap2015

    • Author(s)
      Hayashi A, Yokoyama J, Sato R, Yoshizawa H, Tanaka R, Natori Y, Ohba S, Fukumura Y, Arakawa A, Mizuno H
    • Journal Title

      Plast Reconstr Surg Glob Open.

      Volume: 3 Issue: 3 Pages: e329-e329

    • DOI

      10.1097/gox.0000000000000296

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Volumetric comparison of positron emission tomography/computed tomography using 4′-[methyl-11C]-thiothymidine with2-deoxy-2-18F-fluoro-D-glucose in patients with advanced head and neck squamouscell carcinoma2015

    • Author(s)
      .K Ito, J Yokoyama, Y Miyata, J Toyohara,M Okasaki, R Minamimoto, M Morooka, K Ishiwata
    • Journal Title

      Nuclear Medicine Communications

      Volume: 36 Issue: 3 Pages: 219-25

    • DOI

      10.1097/mnm.0000000000000241

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Advantages of superficial femoral vein grafts for carotid artery reconstruction following carotid artery resection in the treatment of head and neck cancer.2015

    • Author(s)
      J Yokoyama, M Yazawa , H Yoshimoto, S Matsuo, S Ohba
    • Journal Title

      Acta Oto-Laryngologica

      Volume: 135 Issue: 3 Pages: 302-306

    • DOI

      10.3109/00016489.2014.956336

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Significant Preservation of Swallowing Function in Chemoradiotherapy for Advanced Head and Neck Cancer by Prophylactic Swallowing Exercise.2014

    • Author(s)
      S Ohba, J Yokoyama, M Kojima, M Fujimaki, T Anzai, H Komatsu, K Ikeda
    • Journal Title

      Head Neck

      Volume: online Issue: 4 Pages: 23913-23913

    • DOI

      10.1002/hed.23913

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Relation between insulin-like growth factor-1 receptor and human papilloma virus in patients with oropharyngeal cancer2014

    • Author(s)
      F Matsumoto, M Fujimaki, S Ohba, M Kojima, J Yokoyama, K Ikeda.
    • Journal Title

      Head & Neck.

      Volume: online Issue: 7 Pages: 23702-23702

    • DOI

      10.1002/hed.23702

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A novel procedure for transtracheal resection for recurrent thyroid cancer involving a trachea and esophagus2014

    • Author(s)
      S Ohba , J Yokoyama, M Fujimaki ,M Kojima , K Ikeda
    • Journal Title

      World J Surg Oncol.

      Volume: 12 Issue: 1 Pages: 303-303

    • DOI

      10.1186/1477-7819-12-303

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Impact of intra-arterial chemotherapy including internal carotid artery for advanced paranasal sinus cancers involving the skull base2014

    • Author(s)
      J Yokoyama, S Ohba, M Fujimaki, T Anzai, M Kojima, K Ikeda, M Suzuki, H Yoshimoto and K Inoue.
    • Journal Title

      British Journal of Cancer

      Volume: 111 Issue: 12 Pages: 2229-34

    • DOI

      10.1038/bjc.2014.501

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Impact of EPA nutritional approach on cachexic patients with advanced hypopharyngeal cancer treated by induction chemotherapy.2014

    • Author(s)
      Ryota Yoshii, Junkichi Yokoyama, Shinichi, Ohba, Mitsuhisa Fujimaki, Masataka Kojima, and Katsuhisa Ikeda
    • Journal Title

      Head and Neck Oncology

      Volume: 10 Pages: 18-18

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A novel procedure for reconstruction utilizing superficial femoral vein grafts following en bloc resection of carotid artery and head and neck malignant tumors2014

    • Author(s)
      J Yokoyama , M Yazawa, H Yoshimoto, S Ohba.
    • Journal Title

      Interactive CardioVascular and Thoracic Surgery

      Volume: 19 Issue: 2 Pages: 175-7

    • DOI

      10.1093/icvts/ivu112

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prognostic value of post-treatment 18F-FDG PET/CT for advanced head and neck cancer after combined intra-arterial chemotherapy and radiotherapy.2014

    • Author(s)
      K Ito, K Shimoji, Y Miyata, K Kamiya, R Minamimoto, K Kubota, M Okasaki, M Morooka, J Yokoyama.
    • Journal Title

      Chin J Cancer Res

      Volume: 26 Pages: 30-7

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Impact of removing mastoid process for advanced parotid cancer on facial nerve identification, preservation and reconstruction2014

    • Author(s)
      J Yokoyama, S Ooba, M Fujimaki, T Anzai, M Kojima, K Ikeda.
    • Journal Title

      Head & Face Medicine

      Volume: 10 Issue: 1 Pages: 10-6

    • DOI

      10.1186/1746-160x-10-6

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prognostic value of post-treatment 18F-FDG PET/CT for advanced head and neck cancer after combined intra-arterial chemotherapy and radiotherapy2014

    • Author(s)
      Kubota, M Okasaki, M Morooka, J Yokoyama.
    • Journal Title

      Chin J Cancer Res

      Volume: 26 Pages: 30-37

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of Indocyanine Green Fluorescent Image-Guided Surgery for Parapharyngeal Space Tumors.2013

    • Author(s)
      J Yokoyama, S Ooba, M Fujimaki, T Anzai, R Yoshii, M Kojima, K Ikeda
    • Journal Title

      J Cranio-Maxillofacial Surgery

      Volume: - Issue: 6 Pages: 835-838

    • DOI

      10.1016/j.jcms.2013.12.001

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Histological subtypes and characteristic structures of HPV-associated oropharyngeal carcinoma; study with Japanese cases.2013

    • Author(s)
      M Fujimaki, Y Fukumura, K Mitani, A Kurisaki, J Yokoyama, K Ikeda and T Yao
    • Journal Title

      Diagnostic Pathology

      Volume: 8 Issue: 1 Pages: 211-211

    • DOI

      10.1186/1746-1596-8-211

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Significant improvement in superselective intra-arterial chemotherapy for advanced paranasal sinus cancer by using Indocyanine green fluorescence.2013

    • Author(s)
      Yokoyama J, Ohba S, Fujimaki M, Kojima M, Suzuki M, Ikeda K.
    • Journal Title

      Eur Arch Otorhinolaryngol

      Volume: - Issue: 10 Pages: 2795-2801

    • DOI

      10.1007/s00405-013-2846-9

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Minimally invasive procedure for reconstruction through2013

    • Author(s)
      Yokoyama J, Ohba S, Fujimaki M, Ito S, Kojima M, Anzai T, Yoshii R, and Ikeda K
    • Journal Title

      Head Neck Oncol

      Volume: 5 Pages: 1-6

    • DOI

      10.2147/ott.s42006

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Novel application of a polyglycolic acid sheet in treating2013

    • Author(s)
      Ohba S, Yokoyama J, Fujimaki M, Ito S, Matsumoto F, Ikeda K
    • Journal Title

      Head Neck Oncol

      Volume: 5 Pages: 3-3

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 再発頭蓋底浸潤癌に動注療法の血流分布の確認にICG蛍光内視鏡の有用性の検討2016

    • Author(s)
      横山純吉、大峡慎一
    • Organizer
      日本頭頸部外科学会
    • Place of Presentation
      名古屋市
    • Year and Date
      2016-01-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 中咽頭癌側壁進行癌に経口的切除とSet-back tongue flapによる誤嚥防止の工夫2015

    • Author(s)
      横山純吉,大峡慎一
    • Organizer
      日本嚥下医学会
    • Place of Presentation
      福島市
    • Year and Date
      2015-02-06 – 2015-02-07
    • Related Report
      2014 Research-status Report
  • [Presentation] 頭頸部癌における低侵襲的頸部リンパ節制御法2014

    • Author(s)
      横山純吉
    • Organizer
      第29回耳鼻咽喉科腫瘍セミナー
    • Place of Presentation
      大阪市
    • Year and Date
      2014-09-13
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 最新の喉頭癌診断と治療の現況2014

    • Author(s)
      横山純吉
    • Organizer
      板橋区医師会喉頭癌検診研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-31
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 副咽頭間隙悪性腫瘍に対する内視鏡補助下経口法の有用性2014

    • Author(s)
      大峡慎一、横山純吉、小島雅貴、安齋崇,藤巻充寿、池田勝久
    • Organizer
      日本頭頸部癌学会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-12 – 2014-06-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 癌治療におけるEPA栄養剤による支持療法の現況2014

    • Author(s)
      横山純吉
    • Organizer
      日本頭頸部癌学会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-12 – 2014-06-13
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 内頸動脈を栄養血管とする副鼻腔進行癌に対する内頸動脈動注療法の有効性の検討2014

    • Author(s)
      横山純吉、大峡慎一,小島雅貴、安齋崇,藤巻充寿、池田勝久
    • Organizer
      日本頭頸部癌学会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-12 – 2014-06-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 中咽頭側壁悪性腫瘍の経口腔的切除術後の形態と機能の検討2014

    • Author(s)
      横山純吉
    • Organizer
      第24回 頭頸部外科学会
    • Place of Presentation
      香川県高松市
    • Related Report
      2013 Research-status Report
  • [Presentation] 当科における喉頭気管分離術の検討2014

    • Author(s)
      横山純吉
    • Organizer
      第37回 嚥下医学会
    • Place of Presentation
      東京都竹橋
    • Related Report
      2013 Research-status Report
  • [Presentation] 副鼻腔進行癌に動注療法時の血流分布の確認にICG(Indocyanine Green) 蛍光法の有用性の検討2013

    • Author(s)
      横山純吉
    • Organizer
      日本耳鼻咽喉科学会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Research-status Report
  • [Presentation] 頭頸部癌における近赤外蛍光イメージングを用いたNavigation surgeryの有用性の検討2013

    • Author(s)
      横山純吉
    • Organizer
      第37回 頭頸部癌学会
    • Place of Presentation
      東京都新宿
    • Related Report
      2013 Research-status Report
  • [Presentation] 咬筋内神経鞘腫の1例2013

    • Author(s)
      横山純吉
    • Organizer
      第8回小児耳鼻咽喉科
    • Place of Presentation
      群馬県前橋市
    • Related Report
      2013 Research-status Report
  • [Presentation] 広範囲血管浸潤を伴う巨大な甲状腺癌低分化癌(疑)の縦隔進展例2013

    • Author(s)
      横山純吉
    • Organizer
      第46回甲状腺学会
    • Place of Presentation
      名古屋市
    • Related Report
      2013 Research-status Report
  • [Presentation] Usefulness of Superselective Intra-arterial Chemotherapy2013

    • Author(s)
      横山純吉
    • Organizer
      16th ARSR(国際学会)
    • Place of Presentation
      東京都
    • Related Report
      2013 Research-status Report
  • [Presentation] 編集委員会会議2013

    • Author(s)
      横山純吉
    • Organizer
      第51回 癌治療学会
    • Place of Presentation
      京都市
    • Related Report
      2013 Research-status Report
  • [Book] ICG Fluorescent Imaging and Navigation Surgery ICG Fluorescent Image-Guided Surgery in Head and Neck Cancer.2015

    • Author(s)
      Mitsuo Kusano, Norihiro Kokudo, Masakazu Toi, J Yokoyama, S Ohba
    • Total Pages
      474
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report
  • [Book] 神経症候群 第2版2014

    • Author(s)
      横山純吉
    • Total Pages
      5
    • Publisher
      日本臨床
    • Related Report
      2014 Research-status Report
  • [Book] JOHNS2014

    • Author(s)
      横山純吉
    • Total Pages
      4
    • Publisher
      東京医学社
    • Related Report
      2014 Research-status Report 2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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