| Project/Area Number |
25462693
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kyorin University (2014-2015)
Juntendo University (2013) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Hasegawa Yasuhisa 愛知県立がんセンター, 研究所, その他 (10261207)
Ohba Shinichi 順天堂大学, 医学部, 准教授 (20549274)
Ikeda Katuhisa 順天堂大学, 医学部, 教授 (70159614)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | リンパ管化学療法 / センチネルリンパ節 / 低侵襲治療 / ドラッグデリバリーシステム / targeting Chemotherapy / navigation surgery / ICG蛍光法 / Targeting chemotherapy / Navigation surgery |
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| Outline of Final Research Achievements |
Neck lymph node metastasis is the most significant prognostic factor of head and neck cancer. According to the Sentinel theory, metastatic lymph nodes are directly connected with primary tumors via lymphatic canals. Lymphatic chemotherapy is defined as chemotherapy using lymphatic canals between metastatic lymph nodes and primary tumors. As an ultimate cancer treatment which is both highly effective and noninvasive, the current study is to establish a novel lymphatic chemotherapy targeting metastatic lymph nodes in patients with head and neck cancer using anti-cancer drugs combined with micelle. The ICG fluorescence imaging effectively reveals the lymphatic vessels to the metastatic lymph nodes in real time.
We have evaluated the usefulness of lymphatic chemotherapy targeting neck metastases in patients with head and neck cancer by measuring CDDP concentrations in metastatic lymph nodes and pathological effects
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