Molecular mechanisms of the onset of chronic tonsillitis induced by new type of cytokine, IL-17 Development of hearing aid applied to the ear drum directly driven by vibration

Research Project

Project/Area Number	25462694
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Otorhinolaryngology
Research Institution	Juntendo University
Principal Investigator	Ichihari Yukiko 順天堂大学, 医学部, 准教授 (30327803)
Co-Investigator(Kenkyū-buntansha)	KUSUNOKI Takeshi 順天堂大学, 医学部, 教授 (30248025) IKEDA Katsuhisa 順天堂大学, 医学部, 教授 (70159614)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	扁桃炎 / IL-17 / CD4 / リンパ球 / 習慣性扁桃炎 / 扁桃肥大 / 病巣感染症 / CD4+
Outline of Final Research Achievements	We demonstrated the relevance of IL-17 to chronic tonsillitis, tonsillar hypertrophy, and focus infection. The expression of IL-17 protein was investigated by FACS and Western blotting using tonsillar lymphocytes and peripheral blood lymphocytes. The localization and expression of IL-17 was differed among several disorders. The B cells inside tonsillar tissues stimulated by pokeweed mitogen resulted in a significant contribution to production of IL-17 antibodies.

Report

(4 results)