Molecular mechanisms of the onset of chronic tonsillitis induced by new type of cytokine, IL-17 Development of hearing aid applied to the ear drum directly driven by vibration

• Project/Area Number: 25462694
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Juntendo University
• Principal Investigator: Ichihari Yukiko 順天堂大学, 医学部, 准教授 (30327803)
• Co-Investigator(Kenkyū-buntansha): KUSUNOKI Takeshi 順天堂大学, 医学部, 教授 (30248025) ; IKEDA Katsuhisa 順天堂大学, 医学部, 教授 (70159614)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 扁桃炎 / IL-17 / CD4 / リンパ球 / 習慣性扁桃炎 / 扁桃肥大 / 病巣感染症 / CD4+

Outline of Final Research Achievements

We demonstrated the relevance of IL-17 to chronic tonsillitis, tonsillar hypertrophy, and focus infection. The expression of IL-17 protein was investigated by FACS and Western blotting using tonsillar lymphocytes and peripheral blood lymphocytes. The localization and expression of IL-17 was differed among several disorders. The B cells inside tonsillar tissues stimulated by pokeweed mitogen resulted in a significant contribution to production of IL-17 antibodies.

Research Products

• [Journal Article] Novel scoring system and algorithm for classifying chronic rhinosinusitis: The JESREC Study. (2015)
  • Author(s): Tokunaga T, Sakashita M, Haruna T, Asaka D, Takeno S, Ikeda H, Nakayama T, Seki N, Ito S, Murata J, Sakuma Y, Yoshida N, Terada T, Morikura I, Sakaida H, Kondo K, Yamada K, Okano M, Ohtori N, Yoshikawa M, et al
  • Journal Title: Allergy Volume: Epub ahead of print Issue: 8 Pages: 995-1003
  • DOI: 10.1111/all.12644
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effectiveness of lucocorticosteroid for postoperative recurrence of nasal polyps in chronic rhinosinusitis associated with asthma. (2015)
  • Author(s): Ikeda K, Kusunoki T, Saitoh T, Yao T, Kase K, Minekawa A, Inoshita A, Yokoi H, Kawano K.
  • Journal Title: J Otol Rhinol Volume: S1 Pages: 6-9
  • DOI: 10.4172/2324-8785.s1-002
  • Peer Reviewed / Open Access
• [Journal Article] Correlations between Cu,Zn-SOD and macrophages or MUC5AC in human eosinophilic chronic rhinosinusitis. (2015)
  • Author(s): Kusunoki T, Ono N, Ikeda K.
  • Journal Title: J Otol Rhinol Volume: S1 Pages: 10-14
  • DOI: 10.4172/2324-8785.s1-003
  • Peer Reviewed / Open Access