The study for tissue engineered peripheral nerve regeneration preventing from misdirection
| Project/Area Number |
25462698
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | The Tazuke Kofukai |
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Principal Investigator |
KANEMARU Shinichi 公益財団法人田附興風会, 医学研究所 第5研究部, 研究主幹 (00271510)
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| Co-Investigator(Kenkyū-buntansha) |
山下 勝 京都大学, 医学研究科, 助教 (10635519)
中村 達雄 京都大学, ウイルス・再生医科学研究所, 准教授 (70227908)
前谷 俊樹 公益財団法人田附興風会, 医学研究所 第5研究部, 研究員 (90346669)
金井 理絵 公益財団法人田附興風会, 医学研究所 第5研究部, 研究員 (30574008)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 神経再生 / 過誤支配 / 人工神経 / コラーゲン / ゼラチンスポンジ / 単核球 / ｾﾞﾗﾁﾝ / ｺﾗｰｹﾞﾝ / ゼラチン |
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| Outline of Final Research Achievements |
It is the most important for functional regeneration of the peripheral nerve to prevent from misdirection. The aim of this study was to select the best scaffold enter into the artificial nerve conduit and to elucidate the role of monocyte in the process of nerve regeneration for the purpose of promoting functional regeneration of the peripheral nerve.
This study showed that the gelatin sponge, we expected at first, was not adequate scaffold for regeneration of the peripheral nerve. We focused on Wallerian degeneration in the early process of nerve regeneration and performed the study of implantation of monocyte as the leading factor for it. However, implantation of monocyte did not promote functional regeneration of the peripheral nerve.
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Report
(5 results)
Research Products
(9 results)
