| Project/Area Number |
25462700
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | 独立行政法人国立病院機構(東京医療センター臨床研究センター) |
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Principal Investigator |
Tokumaru Yutaka 独立行政法人国立病院機構(東京医療センター臨床研究センター), 聴覚平衡覚研究部, 医師 (60245579)
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| Co-Investigator(Kenkyū-buntansha) |
藤井 正人 独立行政法人国立病院機構(東京医療センター臨床研究センター), 聴覚平衡覚研究部, 部長 (70129633)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ヒト乳頭腫ウイルス / 頭頸部癌 / 中咽頭癌 / メチル化 / TP53変異 |
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| Outline of Final Research Achievements |
The human papillomavirus (HPV) is detected in a subset of head and neck squamous cell carcinomas (HNSCC), especially dominant in the tumor of oropharynx. These HPV-positive HNSCCs are less commonly associated with smoking and alcohol exposure, suggesting a pattern of genetic and epigenetic alterations is quite distinct from that of HPV-negative tumors. The p53 tumor suppressor gene plays a critical role in key pathway involving apoptosis and cell cycle control. In addition, DNA promoter hypermethylation is a common feature of human cancers such as p16 methylation. The objective of this study was to clarify the relationship between HPV infection and TP53 mutations, p16 hypermethylation in HNSCC.
HPV infection correlated inversely with not only TP53 mutation but also p16 methylation in HNSCC. HPV associated HNSCC has a molecular profile that is distinct from non-HPV HNSCC, suggesting novel treatment strategies should be needed for those tumors.
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