A honeycom-patterned film in experimental glaucoma filtration surgery
| Project/Area Number |
25462706
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Tomomi Higashide 金沢大学, 大学病院, 講師 (20291370)
Kazuhisa Sugiyama 金沢大学, 医学系, 教授 (80179168)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 緑内障 / トラベクレクトミー / ドラッグデリバリー / 癒着防止 / ハニカムフィルム |
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| Outline of Final Research Achievements |
Pacritaxel released from honeycomb-patterned film promoted bleb survival and IOP decrease. The lowest dose of pacritaxel (0.5 µg) was effective at preventing bleb avascularity without compromising filtration. Compared with mitomycin C eyes, bleb became flattened in pacritaxel-treated eyes. In addtion, the release profile of pacritaxel in our honeycomb-patterned film carrier may be appropriate to suppress the major proliferative stage of wound healing.
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Report
(4 results)
Research Products
(3 results)
