A honeycom-patterned film in experimental glaucoma filtration surgery

Research Project

Project/Area Number	25462706
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Ophthalmology
Research Institution	Kanazawa University
Principal Investigator	Okuda Tetsuhiko 金沢大学, 大学病院, 助教 (10361990)
Co-Investigator(Renkei-kenkyūsha)	Tomomi Higashide 金沢大学, 大学病院, 講師 (20291370) Kazuhisa Sugiyama 金沢大学, 医学系, 教授 (80179168)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000) Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	緑内障 / トラベクレクトミー / ドラッグデリバリー / 癒着防止 / ハニカムフィルム
Outline of Final Research Achievements	Pacritaxel released from honeycomb-patterned film promoted bleb survival and IOP decrease. The lowest dose of pacritaxel (0.5 µg) was effective at preventing bleb avascularity without compromising filtration. Compared with mitomycin C eyes, bleb became flattened in pacritaxel-treated eyes. In addtion, the release profile of pacritaxel in our honeycomb-patterned film carrier may be appropriate to suppress the major proliferative stage of wound healing.