Quantitative assessment of ischemia in retinal vein occlusion

• Project/Area Number: 25462707
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: University of Yamanashi
• Principal Investigator: IIJIMA Hiroyuki 山梨大学, 総合研究部, 教授 (80114362)
• Co-Investigator(Renkei-kenkyūsha): SAKURADA Youichi 山梨大学, 総合研究部, 助教 (90456476)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 虚血 / 網膜静脈閉塞症 / 蛍光眼底造影 / 光覚感度 / 眼底自発蛍光 / 網膜静脈分枝閉塞症 / 静的自動視野計 / 蛍光眼底造影検査 / 網膜虚血 / 視細胞障害 / 光干渉断層計 / 視野感度 / フルオレセイン蛍光造影検査 / 網膜静脈閉塞 / フルオレセイン蛍光眼底造影検査 / 網膜厚

Outline of Final Research Achievements

Retinal capillary non-perfusion area (NPA) in eyes with branch retinal vein occlusion (BRVO) is associated with retinal ischemia, which is a risk factor of vitreous hemorrhages and neovascular glaucoma due to neovascularization. However the quantitative measure of NPA is difficult. We found that the number of absolute scotoma in static perimetry in these eyes is significantly associated with the qualitatively assessed area of NPA. The results indicates that the number of absolute scotoma could be a quantitative measure of retinal ischemia.

Research Products

• [Journal Article] Humphrey視野計でみる網膜疾患 (2016)
  • Author(s): 飯島裕幸
  • Journal Title: 日本眼科学会雑誌 Volume: 120 Pages: 190-209
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 視野検査 (2015)
  • Author(s): 飯島裕幸
  • Journal Title: 眼科 Volume: 57 Pages: 409-413
• [Journal Article] Visual loss and perimetric sensitivity in eyes with retinitis pigmentosa (2013)
  • Author(s): Iijima, H.
  • Journal Title: Japanese journal of ophthalmology Volume: 57 Issue: 6 Pages: 563-7
  • DOI: 10.1007/s10384-013-0271-7
  • Peer Reviewed
• [Journal Article] Two-year results of photodynamic therapy with or without intravitreal ranibizumab for polypoidal choroidal vasculopathy (2013)
  • Author(s): Sakurada, Y. Iijima, H.
  • Journal Title: Journal of ocular pharmacology and therapeutic Volume: 29 Issue: 9 Pages: 832-836
  • DOI: 10.1089/jop.2013.0044
  • Peer Reviewed
• [Presentation] 網膜静脈分枝閉塞症眼の眼底自発蛍光 (2015)
  • Author(s): 飯島裕幸
  • Organizer: 第54回日本網膜硝子体学会総
  • Place of Presentation: 東京国際フォーラム（東京都）
  • Year and Date: 2015-12-04
• [Presentation] 網膜静脈分枝閉塞症における虚血と絶対暗点 (2015)
  • Author(s): 飯島裕幸
  • Organizer: 第69回日本臨床眼科学会
  • Place of Presentation: 名古屋国際会議場（愛知県・名古屋市）
  • Year and Date: 2015-10-22
• [Presentation] Ischemia and Reduced Sensitivity in Branch Retinal Vein Occlusion (2014)
  • Author(s): Iijima H, Sakurada Y, Yoneyama S, Imasawa M
  • Organizer: World Ophthalmological Congress
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
• [Presentation] 網膜静脈分枝閉塞症，黄斑浮腫眼のベバシズマブ治療における視力と中心窩網膜厚 (2013)
  • Author(s): 飯島裕幸，櫻田庸一，河野恭子，有泉俊人，地場奈実，羽鳥公将
  • Organizer: 第67回日本臨床眼科学会
  • Place of Presentation: パシフィコ横浜（横浜市）