| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The change in lamina cribrosa (LC) depth after intraocular pressure (IOP) reduction was confirmed. It was associated with IOP change, age, severity of glaucomatous optic neuropathy, and baseline LC depth. We further found that some eyes with high myopia and high IOP could change their eyeball shape as a response to IOP reduction. Deformed eyeball shape might be affected by high IOP and IOP reduction might reduce scleral deformation in highly myopic eyes with high IOP. We could not detect a significant association between rs4977756 of CDKN2B-AS1 and POAG in a Japanese cohort with high myopia, which suggests that the odds ratio of developing POAG for rs4977756 would not exceed 1.70.
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