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The effect of 17beta-estradiol for uveitis

Research Project

Project/Area Number 25462718
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionNagasaki University

Principal Investigator

FUJIKAWA Azusa  長崎大学, 病院(医学系), 講師 (60363503)

Co-Investigator(Kenkyū-buntansha) TSUIKI Eiko  長崎大学, 医歯薬学総合研究科(医学系), 講師 (30363493)
KITAOKA Takashi  長崎大学, 医歯薬学総合研究科(医学系), 教授 (80234235)
SUZUMA Kiyoshi  長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (80335265)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywordsエストロゲン / 網膜色素上皮 / 組織電気抵抗 / 17βーエストラジオール / TER / TNF-α / VEGF / 眼科 / ぶどう膜炎
Outline of Final Research Achievements

We investigated transepithelial resistance (TER) on porcine retinal pigment epithelium (RPE) after various stimulation added. We used Tumor necrosis factor alpha (TNF-α), 17β-estradiol, vascular endothelial growth factor (VEGF), rebamipide as a stimulation. TER has been reduced to 60% after TNF-α added. But if 17β-estradiol added 2 hour before TNF-α stimulation, the TER was not reduced. We suggest 17β-estradiol prevents TNF-α damage in RPE. TER wasn’t reduced after VEGF added. When rebamipide added 2 hour before TNF-α stimulation, the TER was reduced. We suggest rebamipide doesn’t prevent barrier function of RPE.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (22 results)

All 2016 2015 2014 2013

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Presentation (15 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Less Invasive Corneal Transepithelial Electrical Resistance Measurement Method.2015

    • Author(s)
      Uematsu M, Mohamed YH, Onizuka N, Ueki R, Inoue D, Fujikawa A, Sasaki H, Kitaoka T.
    • Journal Title

      Ocular Surf

      Volume: 14 Issue: 1 Pages: 37-42

    • DOI

      10.1016/j.jtos.2015.07.004

    • NAID

      120006987208

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RETINAL BLOOD FLOW CORRELATES TO AQUEOUS VASCULAR ENDOTHELIAL GROWTH FACTOR IN CENTRAL RETINAL VEIN OCCLUSION.2015

    • Author(s)
      Yamada Y, Suzuma K, Matsumoto M, Tsuiki E, Fujikawa A, Harada T, Kitaoka T
    • Journal Title

      Retina

      Volume: 35 Issue: 10 Pages: 2037-2042

    • DOI

      10.1097/iae.0000000000000595

    • NAID

      120006986895

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A novel in vivo corneal trans-epithelial electrical resistance measurement device.2015

    • Author(s)
      Uematsu M, Mohamed YH, Onizuka N, Ueki R, Inoue D, Fujikawa A, Kitaoka T
    • Journal Title

      J Pharmacol Toxicol Methods

      Volume: 76 Pages: 65-71

    • DOI

      10.1016/j.vascn.2015.08.153

    • NAID

      120006986930

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of corneal safety and intraocular pressure-lowering effect of tafluprost ophthalmic solution with other prostaglandin ophthalmic solutions.2014

    • Author(s)
      Kumagami T, Wakiyama H, Kusano M, Kajiyama A, Miura Y, Uematsu M, Yoneda A, Kurihara J, Suzuma K, Kitaoka T
    • Journal Title

      J Ocul Pharmacol Ther.

      Volume: 30 Issue: 4 Pages: 340-345

    • DOI

      10.1089/jop.2013.0132

    • NAID

      120006986556

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Influence of different additives and their concentrations on corneal toxicity and antimicrobial effect of benzalkonium chloride.2014

    • Author(s)
      Onizuka N, Uematsu M, Kusano M, Sasaki H, Suzuma K, Kitaoka T
    • Journal Title

      Cornea

      Volume: 33 Pages: 521-526

    • Related Report
      2014 Research-status Report
  • [Journal Article] Cyclic stretch and hypertension increase retinal succinate: potential mechanisms for exacerbation of ocular neovascularization by mechanical stress.2014

    • Author(s)
      Kinoshita H, Suzuma K, Maki T, Maekawa Y, Matsumoto M, Kusano M, Uematsu M, Kitaoka T:
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 55 Issue: 7 Pages: 4320-4326

    • DOI

      10.1167/iovs.13-13839

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Retinal blood flow levels measured by laser speckle flowgraphy in patients who received intravitreal bevacizumab injection for macular edema secondary to central retinal vein occlusion.2014

    • Author(s)
      Matsumoto M, Suzuma K, Fukazawa Y, Yamada Y, Tsuiki E, Fujikawa A, Kitaoka T
    • Journal Title

      Retin Cases Brief Rep

      Volume: 8 Issue: 1 Pages: 60-66

    • DOI

      10.1097/icb.0000000000000005

    • NAID

      120006986617

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Evaluation of scleral buckling with chandelier illumination for rhegmatogenous retinal detachment2016

    • Author(s)
      Azusa Fujikawa
    • Organizer
      ARVO2016
    • Place of Presentation
      Seattle州立会議場(Seattle WA, USA)
    • Year and Date
      2016-05-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Retinal blood flow levels after intravitreal ranibizumab for diabetic macular edema.2015

    • Author(s)
      Matsumoto M, Suzuma K, Tsuiki E, Fujikawa A, Kitaoka T
    • Organizer
      15th EURETINA CongressーNice 2015
    • Place of Presentation
      niece Acropolis Nice (France)
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The visual outcome and prognostic factors in open globe ocular injuries2015

    • Author(s)
      Fujikawa A, Kinoshita H, Matsumoto M, Tsuiki E, Suzuma K, Kitaoka T
    • Organizer
      ARVO2015
    • Place of Presentation
      Colorado会議場(Denver CO, USA)
    • Year and Date
      2015-05-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Acute corneal toxicity of Xalatan and some generics.2015

    • Author(s)
      Inoue D, Uematsu M, Yasser HM, Onizuka N, Ueki R, Fujikawa A, Sasaki H, Kitaoka T
    • Organizer
      ARVO2015
    • Place of Presentation
      Colorado会議場(Denver CO, USA)
    • Year and Date
      2015-05-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Benzalkonium chloride of alkyl chain length C12 is safer for corneal epithelium.2014

    • Author(s)
      Uematsu M, Onizuka N, Ueki R, Suzuma K, Kitaoka T
    • Organizer
      13th congress of the International Society ocular
    • Place of Presentation
      金沢文化ホール(日本)
    • Year and Date
      2014-10-09 – 2014-10-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Retinal blood flow levels measured by Laser Speckle Flowgraphy significantly increased after vitrectomy for diabetic macular edema.2014

    • Author(s)
      Matsumoto M, Suzuma K, Tsuiki E, Fujikawa A, Kitaoka T
    • Organizer
      視覚と眼科学研究協会会議(ARVO)
    • Place of Presentation
      オーランド(米国)
    • Year and Date
      2014-05-04 – 2014-05-08
    • Related Report
      2014 Research-status Report
  • [Presentation] Correlation of retina circulation and blood pressure before and after panretinal photocoagulation for diabetic retinopathy.2014

    • Author(s)
      Onizuka N, Uematsu M, Suzuma K, Kitaoka T
    • Organizer
      視覚と眼科学研究協会会議(ARVO)
    • Place of Presentation
      オーランド(米国)
    • Year and Date
      2014-05-04 – 2014-05-08
    • Related Report
      2014 Research-status Report
  • [Presentation] Generation of ciliary epithelium from mouse ES and iPS cells.2014

    • Author(s)
      Kinoshita H, Suzuma K, Kaneko J, Mandai M, Kitaoka T, Takahashi M
    • Organizer
      視覚と眼科学研究協会会議(ARVO)
    • Place of Presentation
      オーランド(米国)
    • Year and Date
      2014-05-04 – 2014-05-08
    • Related Report
      2014 Research-status Report
  • [Presentation] Retinal and choroidal blood flow changes after switching therapy from ranibizumab to aflibercept in exudative age-related macular degeneration.2014

    • Author(s)
      Yoneda A, Suzuma K, Maekawa Y, Tsuiki E, Wakiyama H, Kitaoka T
    • Organizer
      視覚と眼科学研究協会会議(ARVO)
    • Place of Presentation
      オーランド(米国)
    • Year and Date
      2014-05-04 – 2014-05-08
    • Related Report
      2014 Research-status Report
  • [Presentation] Differentiation of forme fruste keratoconus from normal cornea using parameters of corneal tomography, aberration, and biomechanics.2014

    • Author(s)
      Ueki R, Maeda N, Fuchihata M, Koh S, Kitaoka T, Nishida K
    • Organizer
      視覚と眼科学研究協会会議(ARVO)
    • Place of Presentation
      オーランド(米国)
    • Year and Date
      2014-05-04 – 2014-05-08
    • Related Report
      2014 Research-status Report
  • [Presentation] Optical coherence tomography and ultra-wide-field autofluorescence imaging are the useful tools to understand the changes in peripheral retinal lesions2013

    • Author(s)
      Fujikawa Azusa
    • Organizer
      視覚と眼科学術研究協会会議(ARVO)
    • Place of Presentation
      シアトル(米国)
    • Related Report
      2013 Research-status Report
  • [Presentation] An Assessment of the Lesion in Peripheral Retina Using Optical Coherence Tomography and Ultra-Wide-Field Autofluorescence Imaging.2013

    • Author(s)
      Fujikawa Azusa
    • Organizer
      APVRS
    • Place of Presentation
      名古屋国際会議場(名古屋市熱田区)
    • Related Report
      2013 Research-status Report
  • [Presentation] Blood flow changes of the retina and choroid after vitrectomy for epiretinal membrane measured by laser speckle flowgraphy2013

    • Author(s)
      Tsuiki Eiko
    • Organizer
      視覚と眼科学術研究協会会議(ARVO)
    • Place of Presentation
      シアトル(米国)
    • Related Report
      2013 Research-status Report
  • [Presentation] Retinal blood flow levels measured by Laser Speckle Flowgraphy in central retinal vein occlusion as a predictive factor for ischemia and visual loss2013

    • Author(s)
      Matsumoto Makiko
    • Organizer
      視覚と眼科学術研究協会会議(ARVO)
    • Place of Presentation
      シアトル(米国)
    • Related Report
      2013 Research-status Report
  • [Presentation] Oral Kalidiogenase Improved Retinal Blood Flow Levels and Visual Acuity in Diabetic Macular Edema Patients2013

    • Author(s)
      Tsuiki Eiko
    • Organizer
      米国眼科学会議
    • Place of Presentation
      ニューオーリンズ(米国)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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