The effect of 17beta-estradiol for uveitis
| Project/Area Number |
25462718
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Nagasaki University |
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Principal Investigator |
FUJIKAWA Azusa 長崎大学, 病院(医学系), 講師 (60363503)
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| Co-Investigator(Kenkyū-buntansha) |
TSUIKI Eiko 長崎大学, 医歯薬学総合研究科(医学系), 講師 (30363493)
KITAOKA Takashi 長崎大学, 医歯薬学総合研究科(医学系), 教授 (80234235)
SUZUMA Kiyoshi 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (80335265)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | エストロゲン / 網膜色素上皮 / 組織電気抵抗 / 17βーエストラジオール / TER / TNF-α / VEGF / 眼科 / ぶどう膜炎 |
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| Outline of Final Research Achievements |
We investigated transepithelial resistance (TER) on porcine retinal pigment epithelium (RPE) after various stimulation added. We used Tumor necrosis factor alpha (TNF-α）, 17β-estradiol, vascular endothelial growth factor (VEGF), rebamipide as a stimulation. TER has been reduced to 60% after TNF-α added. But if 17β-estradiol added 2 hour before TNF-α stimulation, the TER was not reduced. We suggest 17β-estradiol prevents TNF-α damage in RPE. TER wasn’t reduced after VEGF added. When rebamipide added 2 hour before TNF-α stimulation, the TER was reduced. We suggest rebamipide doesn’t prevent barrier function of RPE.
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Report
(4 results)
Research Products
(22 results)
